丹参注射液对小白鼠缺氧心肌的影响及超微结构的变化

作者	单位
俞国瑞	上海第二医学院附属第三人民医院内科
汤雪明	上海第二医学院附属第三人民医院内科
郑道声	上海第二医学院附属第三人民医院内科
黄铭新	上海第二医学院附属第三人民医院内科
韩玉昇	上海第二医学院电镜室

摘要点击次数: 1296

全文下载次数: 957

中文摘要:

用复方丹参注射液治疗冠心病的临床疗效达80%、心电图改善达60%。关于其作用机理尚不明确,有报告丹参有增加冠状动脉血流量的作用;但亦有报告否定此结论;陈氏等报告用复方丹参后有提高小自鼠耐缺氧作用;我们用丹参获得同样结论。程氏报告复方丹参可改善心肌的血液循环,杨氏认为丹参可改善血粘度。亦有报告认为丹参具

英文摘要:

The authors present an investigation of the effect of injectio Salvia miltiorrhiza(concentration:1.5g/ml)on the ischemic myocardium of mice.The control and treated mice were made to swim in a closed flask containing 2000ml of water and 500ml of air.One pair was taken out from the flask at the end of 15 min.and 4 pairs at 31—36 min.Specimens taken from endocardium and myocardium of apical portion of the heart were investigated under the electromicroscope.No marked change was observed in specimens taken from mice after 15 min. swimming.However,marked ischemic changes were observed in the following:1.Marked edema in the myocardial cell with fragmentation of some of the myofibrils;2.marked swelling of mitochondria showing disruption of its structure and disappearance of the cristae.Some mitochondria also showed myelinization;3. Marked dilatation of the endoplasmic reticular space;4.widening of the intercalated discs;5.Marked folding of the membrane of the nucleus with chromatin precipitates along the internal aspect of the membrane;6. Disappearance of glycogen granules;7.Marked dilatation of capillaries with clumps of RBC and platelets in some of them. The myocardium of mice treated with Salvia miltiorrhiza showed the following changes:1.Slight edema of the myocardial cells with intact M lines of the myofibrils.Small amount of glycogen granules could be seen between the myofibrils;2.Slight edema was observed in some of the mitochondria,and the arrangement of the cristae in most mitochondria was nearly normal;3.No widening of the intercalated discs was shown;4.Slight edema of the endoplasmic reticulum;5.Slight irregularity of the border of the capillaries with only a few RBC seen in each capillary,suggesting an increased rate of blood flow. The authors concluded that the above slight change of the myocardium in the treated mice was probably due to the increase of blood flow after Salvia administration,which had also been demonstrated by capillary microscopic observations.

关闭