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谢全锦,侯灿,吴伟康,何勤.补阳还五汤对球囊扩张主动脉后再狭窄其内皮PDGFR和SOD-1基因表达的探讨[J].中国中西医结合杂志,1997,(10):611-613
补阳还五汤对球囊扩张主动脉后再狭窄其内皮PDGFR和SOD-1基因表达的探讨
Study on Platelet-Derived Growth Factor mRNA and Copper-Zinc Superoxide Dismutase mRNA Expression Changes of Aortic Artery Endothelium with Restenosis after Aortic Artery Dilatation Treated with Buyang Huanwu Decoction
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DOI:
中文关键词:  补阳还五汤  血小板衍化生长因子  铜-锌超氧化物歧化酶  基因表达
英文关键词:Buyang Huanwu Decoction  platelet-derived growth factor  copper-zinc superoxide dismutase  gene expression
基金项目:国家自然科学基金
作者单位
谢全锦 中山医科大学 
侯灿 中山医科大学 
吴伟康 中山医科大学 
何勤 中山医科大学 
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中文摘要:
      目的:探讨补阳还五汤防治经皮腔内冠脉成形术(PTCA)后再狭窄的消长机制。方法:仿PTCA术后再狭窄的新西兰兔模型28只,以原位引物标记法测动脉内皮钢-锌超氧化物歧化酶(SOD-1)及血小板行化生长因子受体(PDGFR)的基因表达,分析再狭窄消长机理。结果:主动脉球囊扩张术后7天,手术部位动脉内皮的SOD-1基因表达增强,与对照组有显著差异(P<0.05),而PDGFRmRNA的表达则减弱,与对照组也有显著性差异(P<0.05)。结论:补阳还五汤增强动脉内皮SOD-1的基因表达,改善缺血再灌注的供氧。同样情况下,补阳还五汤抑制PDGFRmRNA表达,以控制细胞的病理性增殖。
英文摘要:
      Objective: To study on dynamic mechanism of restenosis after PTCA treated with Buyang Huanwu Decoction (BYHWD). Methods: Twenty-eight male New Zealand rabbits with mimic restenosis after aortic artery dilatation were detected by prime in situ labeling in aortic endothelium. The items included gene expression of copper-zinc superoxide dismutase (SOD-1 ) and platelet-derived growth factor receptor (PDGFR) mRNA to analyse dynamic mechanism of restenosis. Results: Seven days after aortic artery dilatation, PDGFR mRNA of aortic endothelium decreased clearly. The comparison between experimental and the control group showed significant difference (P <0. 05). By the same condition, the gene expression of SOD-1 was increasing, which showed a significant difference with the control group (P < 0. 05). Conclusions: BYHWD increased SOD-1 gene expression of artery endothelium,to improve oxygen feed for ischemia reperfusion in the same way, BYHWD suppressed PDGFR mRNA expression to control cellular pathological proliferation.
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