“咳痰敏”治疗慢性气管炎316例临床观察及药理实验

On the basis of past experiences from combining TCM and WM in the treatment and prophylaxis of chronic bronchitis,a new preparation,"Ketanmin"（咳痰敏）in form of tablets,has been prescribed after some steps of screening and summing-up for potent medicinal elements.Ketanmin contains extracts of Houttuynia cordata Thunb.（鱼腥草）,Chrysanthemum indicum（七叶一枝花）,Radix platycodon（桔梗）,Rhizoma Pinelliae （半夏）and Pericarpium Papaveris（罂粟壳）with Aminophylline and Benadryl.316 patients were treated with Ketanmin,each subject taking 3 tablets three times a day during the season with high incidence from December 1978 to March 1979.The patients treated with this new preparation had an over-all effective rate of 80.7% with a prominent improvement rate of 46.85%.Ketanmin has evident effects against cough,expectoration and dyspnea. This preparation is also applicable to all types of chronic bronchitis simple or asthmatic either at the acute episode or at the dwelling phase（P>0.05）;therefore its therapeutic usage is wide-ranged,however,it is less effective to those complicated with ernphysema.Preliminary pharmacological experiments performed on mice showed that Ketanmin inhibited the cough induced by vapour of boiling ammonia.Phenol red tests revealed marked expectòrant action in mice.In guinea pigs,the new preparation showed evident spasmolytic action on tracheal spasm induced with histamine,both in vitro and in vivo.The LD₅₀of the toxicity tests was 2775.5±3.8 mg/kg;clinically,there was no apparent toxic side effect.This drug can easily be processed from herbs and chemicals with rich resources and further tests and study on this drug,Ketanmin,will be worthwhile.

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