芪附注射液对麻醉犬急性心肌缺血、左室功能和血液动力学的影响

作者	单位
李增晞	包头医学院心血管研究室
田风举	包头医学院心血管研究室
吴秀英	包头医学院心血管研究室
田力	包头医学院心血管研究室
石山	包头医学院心血管研究室

摘要点击次数: 1536

全文下载次数: 996

中文摘要:

芪附汤为中医"益气温阳"和"回阳救逆"的主要方剂,我们曾观察到芪附注射液具有明显提高动物耐缺氧的能力,对急性心肌缺血和心律失常亦有显著的保护和对抗作用。本文拟进一步研究芪附注射液对麻醉犬急性心肌缺血、左室功能和血液动力学的影响,为阐明其作用机理及临床治疗提供必要的实验依据。

英文摘要:

Qi-Fu Tang(芪附汤.a solution made of 黄芪 Radix Astragali and 附子 Radix Aconiti Carmichaeli Praeparata)is one of the main recipes of the TCM,the effect of which is"Yi Qi Wen Yang,益气温阳"(the replenishment of vital energy and the promotion of Yang)and"Hui Yang Jiu Ni 回阳救逆"(the restoration of Yang from collapse). In this work the effect of Qi-Fu Injection on the myocardial ischemia,the left cardiac ventrieular function and hemodynamics in anesthetized open-chest dogs was studied.The results of our study are:1.a remarkable change in ST-segment on epicardial ECG was observed.↑ and NST↑% in animals with Qi-Fu Injection(Qi and Fu50 mg/kg Ⅳ)decreased after the ligatiou of the coronary artery in 1-20 minutes compared with those in animals with ligation only;2.changes in left ventricular function and hemodynamies measurements were noticed.In animals with Qi-Fu Injection after the ligation of the coronary artery,the decrease of the heart rate and blood pressure slowed down significantly the dp/dt,the left ventrieular work index,the tension-time index and the myocardial volume oxygen index dropped greatly,and the stroke index increased markedly;3.the process of thinning in the thickness of the left ventricular anterior wall were markedly eased.The left ventricular end-diastolic anterior wall thickness was reduced by about 26-27% when the coronary was simply ligated, whereas in the case when ligation was preceded by the administration of Qi-Fu,the ventricular wall thickness remarkably increased,i.e.,20-70% greater than the former.These findings suggest that Qi-Fu may significantly reduce the amplitude and amounts of increasing ST-segment in the myocardial ischemic zone and decrease the degree of ischemie and the injured range.Qi-Fu Injection possesses negative chronotropic and negative inotropic actions on ischemic myocardia.It can reduce the tension in the walls of the ventricle and left ventricular afterload,and increase the cardiac efficiency and output of the isehemic heart when oxygen and energy are supplied insufficiently.This is advantageous to the increase in blood flow and the supply of oxygen and energy. As the consumption of oxygen and energy of heart is decreased simultaneously,the balance between the supply and demand of oxygen is improved.

关闭