豚鼠哮喘时微循环变化及中药对哮喘防治的实验研究

作者	单位
丁钰熊	上海第二医学院中医教研室
龙楚瑜	上海第二医学院中医教研室
徐建中	上海第二医学院中医教研室
钱永益	上海第二医学院中医教研室
李行能	上海第二医学院中医教研室
龚上智	上海第二医学院中医教研室

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中文摘要:

哮喘之病,反复发作,不仅久病及肾,也必涉及到心主血脉功能。本文观察了实验性喘哮动物的微循坏变化及杏仁、桃仁、地龙煎剂对实验性哮喘的防治作用。实验方法一、微循环观察:选用健康纯白豚鼠,体重250g左右,以2.5%戍巴比妥钠麻醉后观察豚鼠耳微循环。用冷光源45°斜照,显微镜放大80倍,用目微尺测

英文摘要:

In order to observe microcirculation,the normal guinea pigs that were narcotized by 2.5% mebubarbital on their ears formed the control group,whereas those injected with histamine phosphates and those sprayed with 0.3% histamine phosphates formed the experimental groups.Observation showed that the injected group had no evident change,but the sprayed group had peripheral microcirculation disturbances.The blood flow of the latter changed from normal beltlike lines to granular or dotted ones and the flowing speed of the blood stream slowed down obviously,which was markedly slower than that in the control group(p<0.001).The color of the blood was dark red.Arterioles,venules and capillaries were evidently dilated.Exudation could be found obviously in some parts of microcirculation.The experimental results were on the whole similar to the nail-fold.nicrocirculation in asthma patients reported in the literature.This suggests that asthma had a close relation to vital energy and blood in addition to the lung,spleen and kidney,which directly affect its incidence and development. In another experiment,guinea pigs were divided into 3 groups—the control group,the traditional Chinese herb group(杏仁 Prunus armeniaca,桃仁 Prunuspersica,地龙 Lumbricus spencer)and the western medicine group (Aminophylline),so as to observe the time needed to induce asthma after a spray of histamine phosphates.After oral administration,the control group averaged 72.07 sec,the aminophylline group averaged 116.86 sec and the traditional Chinese herb group 195.73 sec.The induction of asthma was markedly slower in the animals of the. experimental groups as compared with those in the control group(p<0.001),and it was even slower in the animals of the traditional Chinese herb group than those in the aminophylline group(p<0.02). In short,the traditional Chinese herbs aimed for vital energy and blood are effective to a certain extent in the prevention of experimental asthma.

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