乌头类中药中毒所致心律失常五例报告

乌头(Aconitum chinense)类中药中毒所致心律失常,文献报告不多。我院于1976年～1980年共收治五例,均全部治癒,现报告如下:临床资料5例全部为男性患者,年龄最小32岁,最大60岁。4例因类风湿、风湿性关节炎自服乌头类中药单方,1例误服外用乌头药酒所致。药物制剂及剂量:1例误服川乌、草乌生药外用

英文摘要:

5 male patients ranging 32-60 years of age with arrhythmia reduced by aconitine poisoning because of overdosage through oral administration or accidental intoxication were studied.The incubation period was found to vary from 2-4 hours. The main clinical manifestations were(1)Digestive system:nausea,vomiting,heartburn;(2)Nervous system: vexation convulsion,sensation of numbness,loss of consciousness.(3)Circulatory system:dyspnea,palpitation,cold sweat,hypotension shock and arrhythmia.Electrocardiograms demonstrated APC and VPC,ventricular bigeminy, ventricular parasystole;multifocal APC and VPC;supraventricular and ventricular tachycardia;AV junctional escape rhythms,varying degrees of AV block;ventricular fibrillation,ST segment elevation and T wave flat or inversion. Aconitine was found to be divided into two par-aconitum,i.e.,Aconiturn carmichaeli Debx and Aconitum Chinense Paxt(including Radix Aconiti,Aconitum brachypodum Diels),both characterized as being pungent and hot and extremely poisonous.The first of these mechanisms to be considered is increase in vagus nerve tone and supression of impulse formation disturbance(passive arrhythmia);the second important mechanism to be considered is enhanced automaticity.This term is used to describe an increased rate of spontaneous discharge from subsidiary or ectopic pacemaker tissue because of its direct intoxicational effects(active arrhythmia).

关闭