| 张肇和.茜草双酯升白细胞作用的临床观察[J].中国中西医结合杂志,1983,(2):98-99,68 |
| 茜草双酯升白细胞作用的临床观察 |
| Clinical Observation on Diethylester Rubia Cordifolia L.Promoting the Increase of Leucocyte Count in Leucopenia |
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| 中文关键词: 茜草科 升白细胞 白细胞数 茜草双酯 白细胞减少 升白作用 利血生 维生素 新作用 化学分析 |
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| 中文摘要: |
| 茜草(Rubia Cordifolia L.)为茜草科植物,系多年生蔓草,药用其根茎,性苦寒,入肝经。有凉血止血、活血化瘀,去瘀生新作用。从茜草的提取物进行化学分析,发现茜草酸甙Ⅰ和Ⅱ为萘醌化合物,均有升白细胞(下称升白)作用。人工合成的1,4萘酚2,3二羧酸乙酯属茜草酸衍生物,简称茜草双酯。我院 |
| 英文摘要: |
| Diethylester Rubia Cordifolia L.（DRC）is a kind of synthetic drug.This study is to extend the field of its application to leucopenia of various causes.It was used on 4 kinds of patients with a dosage of 200mg t.i.d.,most of them being children.Group Ⅰ:Viral or bacterial infection（viral URI 2 cases,viral URI with myocarditis 1 case,and marasmus with septicemia by colon bacilus 1 case）with a leucocyte count ranging 1,650-3,500/mm3.All of them had an increase of 1,300-3,500/mm3 in 24-96 hours after medication.Group Ⅱ:A group of 3 patients with leucopenia. One of them,was a woman laborer who had worked in a benzine workshop for 3 years.Another case was a 12 year- old boy with nephrotic syndrome who had suffered from leucopenia after immunosuppressive therapy with Cyx for 118 days The third patient had been on chemotherapy with actinomycin D and VCR after the resection of a huge Wilm’s tumor.Results have indicated that DRC is even more potential in promoting the incrcse of leucocyte count than the commonly used drugs such as leucogen,vit.B4 and butylalcohol.Group Ⅲ:2 cases of acute lymphocytic leukemia with extremely low leucocyte count after VP（WBC 40,500 decreased to 1,700）and VMP regime（WBC 13,400 dropped to 550）,Following the use of DRC along with leucogen,vit.B4 and butytalcohol,WBC increased without suspension of the antilenkemic therapy,thus they have synergetic action.Group Ⅳ:A 23-year-old male adult with aplastic anemia for 3 years.It was not clear to which type it belonged.Although DRC had been used for 3 months,no effect was obtained. |
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