| 陈锐群,张夏英,郑境娟,余竹元,顾天爵.阴虚内热证初探——知母对钠泵作用的大鼠体内实验[J].中国中西医结合杂志,1983,(4):235-236,196 |
| 阴虚内热证初探——知母对钠泵作用的大鼠体内实验 |
| A Preliminary Study of Internal Heat Due to Deficiency of Yin —The Sodium Inhibitory Action of Anemerrhena Rhizome in Vivo |
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| DOI： |
| 中文关键词: 甲状腺素 阴虚内热证 知母 钠泵活性 大鼠 正常对照组 耗氧率 重要地位 小肠粘膜 能量代谢 |
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| 中文摘要: |
| 中医的"阴虚内热","阳虚外寒"和能量代谢有否内在联系?是许多研究工作者所关注的问题。七十年代初,Edelman 等提出细胞中消耗能量最多的是钠泵(Na~+、K~+-ATP 酶)。钠泵所消耗的能量估计占整个细胞总能量的40～60%。因此,在机体热生成中占重要地位。这个理论为许多实验所证实。那么,阴虚内热是否与钠泵相关呢?这是一个 |
| 英文摘要: |
| It was mentioned in our previous report that a kind of saponin from Anemarrhena Rhizome had been isolated.The saponin and its hydrolytic product,sapogenin,are potential inhibitors of sodium pump in vitro.In this paper,the sodium pump inhibitory action of the sapogenin in vivo is reported.Eighteen rats were divided into three groups—control,thyroxine group and thyroxine plus sapogenin group.The duration of drug administration was three weeks.Then the animals were killed and the sodium pump activity of four organs(liver,kidney,the mucous membrane of the small intestine and brain)were measured.The results revealed that the activity of the three organs(liver,kidney and the mucous membrane of the small intestine)were markedly induced by the thyroxine and the induced enzyme can be inhibited totally by the sapogenin in vivo.Significances of the result are discussed. |
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