滋肾阴、温肾阳中药对大鼠下丘脑—垂体—肾上腺皮质轴受抑模型的作用——肾上腺皮质束状带超微结构观察

Action of"Nourishing Shen Yin"and"Warming Shen Yang"Drugs on An HPA Axis-Inhibited Model in Rats—An Ult astructural Observation of Fasciculata Zone of Adrenal Cortex

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中文关键词: 细胞线粒体肾上腺皮质束状带细胞超微结构观察血浆皮质酮地塞米松温肾阳超微结构变化实验补肾中药下丘脑

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基金项目:

作者	单位
杨连卿	上海第一医学院华山医院脏象研究室
沈自尹	上海第一医学院华山医院脏象研究室
钟慈声	上海第一医学院电子显微镜实验室
施凤英	上海第一医学院华山医院脏象研究室
张新民	上海第一医学院华山医院脏象研究室
陈素珍	上海第一医学院华山医院脏象研究室

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中文摘要:

本实验以外源性糖皮质激素地塞米松灌胃,建立动物下丘脑—垂体—肾上腺皮质(HPA)轴功能受抑模型;采用电子显微镜、光学显微镜以及血浆皮质酮放射免疫测定等技术手段,从形态和功伯两方面,着重从肾上腺皮质束状带细胞超微结构变化,研究补肾中

英文摘要:

An HPA axis function-inhibited model of rats was established in this series by the administration of glucoeorticosteroids Dexamethasone.For the sake of seeking characteristics of"Nourishing Shen Yin"and "Warming Shen Yang"drugs during various stages,the effect of reinforcing Shen drugs on the model was quanti- tatively studied,morphologically and functionally by means of studying the ultrastructure of fasciculata zone of adrenal cortex along with other methods,such as light microscopy and radioimmunoassay of plasma corticosterone. 170 Wistar adult male rats were taken,and randomly divided into four groups according to different drugs administered:group of Dexamethasone(D),group of Dexamethasone and"Nourishing Shen Yin"drugs(DYi), group of Dexamethasone and"Warming Shen Yang"drugs(Dya),and the control group(C). 7-day and 30-day experiments were carried out separately.The results indicate that the function of the HPA axis in D group and DYa group in the 7-day experiment and in D group and DYi group in the 30-day experiment were significantly lower than that of the HPA axis in C group and DYi group in the 7-day experiment and in C group and DYa,group in the 30-day experiment respectively. These results,in association with the radioimmunoassay of~3 H-plasma cortieosterone and the measurement of the size of nucleus of fasciculata zone cells in all the four groups,indicate that"Warming Shen Yang"and "Nourishing Shen Yin"drugs of TCM may protect the function of HPA axis in rats from the suppressive activity caused by an extra source of glucocortieosteroids,and that in the early stage(7-day),the protective action of "Nourishing Shen Yin"drugs was much more effective than"Warming Shen Yang"drugs,and the latter’s action was suitable for the later stage(30-day).

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