凉血活血、激素、清热解毒对淤胆型肝炎退黄疗效的比较

Comparison of Jaundice-Reducing Effects of Drugs for Eliminating Pathogenic Heat from Blood and Invigorating Blood Circulation,Corticosteroids,and Toxic Heat-Removing Drugs in the Treatment of Cholestatic Hepatitis

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中文关键词: 清热解毒方淤胆型肝炎凉血活血血清胆红素有效率激素退黄作用清热解毒中药用药疗效

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作者	单位
汪承柏	中国人民解放军302医院
陈菊梅	中国人民解放军302医院
贺江平	中国人民解放军302医院
雷周云	中国人民解放军302医院

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中文摘要:

经回顾性总结对比了凉血活血、激素、清热解毒对淤胆型肝炎的顿挫与退黄效果,三组顿挫黄疸有效率为90.91、65.0、22.72%;退黄有效率为92.3、65、28%。对有效病例凉血活血与激素组的用药时胆红素平均值,降至10及5mg%以下的平均天数相似。激素治疗无效者凉血活血治疗有效。

英文摘要:

This article reviews our experiences in the past ten years and compares the jaundice- reducing and inhibiting effects of the drugs for eliminating pathogenic heat from blood and invigorating blood circulation with heavy dose of Radix Paeoniae Rubra,corticosteroids,and toxic heat-removing drugs in our treatment of cholestatic hepatitis.The diagnosis of all the 46 cases as established clinically and/or pathologically.As some of the patients were shifted to another kind of drugs after a period of treatment with certain drugs which failed to reduce the jaundice or even made it worse,58 case/time were in fact involved in the treatment,that is,13 with drugs for eliminating pathogenic heat from blood and invigorating blood circulation, 20 with toxic heat-removing drugs,and 25 with corticosteroids.The treatment was taken as effective when the total serum bilirubin was reduced by 20% and kept decreasing after 12 days of treatment.Their effective rates were 92.3%,65.0% and 28.0% respectively.The treatment was also taken as effective when the increasing jaundice of the patients stopped after the administration of drugs.Their effective rates were 90.99%,65.0% and 22.7% respectively.The average days taken to reduce the mean value of bilirubin to 10 and 5mg% were similar between the patients given drugs for eliminating pathogenic heat from blood and invigorating blood circulation and those given corticosteroids.This shows that the jaundice reducing speed of these two kinds of drugs in responsive cases were similar.As both the total effective rates of corticosteroid to cholestatic hepatitis and the effective rates in inhibiting the jaundice are lower than those of herbal medicines for eliminating pathogenic heat from blood and invigorating blood circulation,it is suggested that corticosteroid should not be the drugs of first choice in the treatment of cholestatic hepatitis.The toxic heat-removing drugs have good effect in reducing and inhibiting jaundice in the cases with heavy jaundice complicated with dampness and heat,but they effect poorly on cholestatic hepatitis.This is probably due to the different causes and mechanism of cholestatic hepatitis in which jaundice is complicated with stagnant heat.

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