活血化瘀治疗小儿腺病毒性肺炎的机理探讨与电镜观察——附93例小儿腺病毒肺炎合并DIC临床疗效分析

作者	单位
阎田玉	北京友谊医院儿科
龚明敏	北京友谊医院儿科
林胡春	北京友谊医院儿科
周光延	北京友谊医院儿科
孙本韬	山西医学院电镜室

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中文摘要:

本文从临床表现和甲皱微循环、血液流变学及凝血学检查所见,提出了小儿腺病毒肺炎辨"血瘀证"的依据,认为中医血瘀证与西医微循环障碍有其共同的病理基础和临床表现。临床以活血化瘀中药为主治疗婴幼儿腺病毒肺炎654例,病死率从六十年代初期30%左右降至5.66%;活血化癌中药对早期 ARDS 的肺组织电镜观察的动物实验也支持该论点。

英文摘要:

In the past seven years,645 cases of infant adenovirus pneumonia have been treated with Chinese herbal medicine and western medicine combined.The herbs used are those with the action of Huo Xue Hua Yu— invigorating blood circulation and eliminating blood stasis,The mortality rate was reduced from 30% to 5.66%. The most outstanding feature of these patients was the so called"hemostasis"consisting of microcirculatory changes in nail fold,hemorheological changes and DIC.All of these pathopysiological changes improved after treatment.It was assumed that the"hemostasis"in traditional Chinese medicine might be the clinical expression of general microcirculatory disturbances.The electronic microscopic observation on early ARDS in animal provided further support to this hypothesis.The ARDS was induced by thiourea in hamsters. After the administration of the herbal mixture,it was found that:(1)the edema diminished;(2)the pulmonary microcirculation improved with the V/Q ratio and shunt amount readjusted;(3)the damage of alveolor capillaries induced by lysosomal enzymes decreased;(4)pulmonary capillary constriction was prevented;(5)the injured surface was restored after the blood cells,fibrin and protein were cleared from the alveoli. The theory of hemostasis and the therapeutic principle and methods for hemostasis were discussed on the basis of modern medical concepts.

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