| 任文华,黄桂秋,孔润莲.蒲黄对大白鼠巨噬细胞活力及胆固醇肉芽肿的影响[J].中国中西医结合杂志,1984,(3):176-178,193,133 |
| 蒲黄对大白鼠巨噬细胞活力及胆固醇肉芽肿的影响 |
| Effect of Pollen Typhae on Macrophage Activity and Regression of Cholesterol Granuloma of Rats |
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| DOI： |
| 中文关键词: 巨噬细胞功能 胆固醇肉芽肿 大白鼠 脂多糖 巨噬细胞系 蒲黄 腹腔巨噬细胞 溶菌酶活性 动脉粥样硬化病变 弗氏佐剂 |
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| 中文摘要: |
| 本文共观察75只雄性 Wistar 大白鼠,除测其腹部皮下胆固醇肉芽肿重量及总胆固醇含量外,还作血清溶菌酶活性及肺、腹腔巨噬细胞吞菌功能检查,部分动物并肉芽肿电镜等形态观察。结果表明:口服中药蒲黄能激活体内单核—巨噬细胞系统,有利于肉芽肿中脂质的吸收,故加强单核一巨噬细胞系统,可能有助于动脉粥样硬化病变的消退。 |
| 英文摘要: |
| Pollen Typhae is a traditional Chinese herb medicine which has the action of"invigorating blood circulation and climinating venous stasis".It can prevent the hypercholesterolemia of human beings,rats and rabbits,and alleviate rabbit experimental atherosclerotic plaques formation.In order to clarify whether the effects of the drug are due to the activation of macrophage,we have carried out the present studies.An experimental cholesterol granuloma model in Wistar rats was created and the regressive effect of Pollen Typhae on it was observed and compared to that of the immunostimulants Freund adjuvant,lipopolysaccharide,and high molecular dextran. The results showed:(1)Like other immunostimulants,Pollen Typhae per os could activate the monocyte- macrophage system,which is shown in the increase of phagocyte activity and the lysozyme level.(2)Activation of the monocytc-macrophage system contributed to the regression of atherosclerotic plaques by increasing the absorption of the cholesterol. |
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