| 杨任民,鲍远程,杨兴涛,李圣业,陈卫东,娄宗盘.肝豆汤对37例肝豆状核变性驱铜的观察[J].中国中西医结合杂志,1984,(8):462-464,450 |
| 肝豆汤对37例肝豆状核变性驱铜的观察 |
| Observation on Cop er Excretion of 37 Cases of Wilson’s Disease Treated with"Anti-Hepatolenticular Degeneration Decoction" |
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| DOI： |
| 中文关键词: 肝豆状核变性 肝豆汤 血清铜氧化酶 铜代谢障碍 排泄 临床症状 治疗过程 观察 中药 铜蓝蛋白 |
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| 中文摘要: |
| 本文报告中药肝豆汤对37例肝豆状核变性患者体内铜代谢的影响观察。于服药前后作了24小时尿铜排泄、血清铜与血清铜氧化酶活力的对比。结果表明,服肝豆汤后,24小时尿铜排泄增加,且可能对血清铜氧化酶活力有一时性轻度提高,但血清铜水平无变化。 |
| 英文摘要: |
| Copper excretion of 37 cases of Wilson’s disease treated with"Anti-Hepatolenticular Degeneration Decoction"is reported,22 males and 15 females with age ranging from 9 to 58.The course of disease varies from one month to nine years,averaging two or three years.37 patients with Wilson’s disease were given"Anti-Hepatolenticular Degeneration Decoction"which is composed of Rheum officinale Baill 6 to 9 gm;Coptis chinensis Franch.and Scutellaria baicalensis Georgi each 10 gm;Dioscorea hypoglauca Palib,Scutellaria barbata Don and Andrographis paniculata Nees each 20 gm.As a result, 35 cases showed increased copper content in urine,and 2 cases showed decreased copper content.The increase of copper content in urine ranged from 15.to 917μg/24h,with an average increase of 293.975μg/24h(t=4.1689,P<0.01).The serum benzidine oxidase was found increased in 26 cases and reduced in 7 cases with a mean exalt of 0.035(t=2.409,P<0.05).However,the serum copper concentration remained the same.The decoction is characterized by higher therapeutic effect and little side effect.According to the authors,it may be used as a good remedy to improve neural symptom of Wilson’s disease. |
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