健康人口服中药大黄前后的血液流变学观察

健康人一组22例,另一组43例,分别口服单味大黄片剂9g/天和15g/2天。第一组口服两小时后,血液流变学诸指标均无明显变化,只是经24小时后才出现明显变化,且主要见于红细胞压积较高的男性。第二组口服经48小时后均观察到血液流变学诸指标的明显变化,其特点是随着红细胞压积的低高不同显示出血液粘度增高和降低的双相变化。这与上消化道出血患者口服大黄止血后所观察到的结果基本上是相一致的,但与之不同的是血浆渗透压均表现为明显增高。

英文摘要:

Tablets of Rheum palmatum L were given in oral doses 9g per day or 15g every two days(equivalent to dry crude drug weight),to two groups with 22(Group A)and 43(Group B)normal subjects respectively and 6 tests of hemorheology were carried out to check changes in hematocrit,whole blood viscosity,plasma viscosity,erythrocyte sedimentation rate,electrophoretic time of erythrocytes in their own plasma and plasma osmotic pressure.In Group A hematocrit and whole blood viscosity were found to have grown higher 24 hours after taking the tablets.In Group B 48 hours after medication a diphase effect of blood viscosity changes was observed:viscosity increased in subjects with lower hematocrit and vice versa.The results were coincident with clinical findings since patients with upper-digestive tract hemorrhage treated with the drug as a hemostatic gave good therapeutic effect,but the increase of osmotic pressure after medication was something different from clinical results.

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