从大承气汤对血管通透性的影响看祛邪类药物的双向调节作用

作者	单位
孙爱贞	上海中医研究所
王惠芳	上海中医研究所
郭瑞新	上海中医研究所
罗梅初	上海工业卫生研究所
李兰娣	上海工业卫生研究所
张美珍	上海工业卫生研究所
金寿山	上海中医学院

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中文摘要:

本实验采用¹²⁶Ⅰ-白蛋白放射活性,测定多种炎症病理模型动物腹部血管的通透性。实验结果,大承气汤的作用因炎症部位、病程、程度不同表现为多种双向调节效应。但是在药物的影响下,血管通透性并未回到正常水平,祛邪方药大承气汤与扶正方药的双向调节似有不同之处。双向调节作用因戊巴比妥钠的麻醉而丧失。

英文摘要:

This paper reports the biphasic effect of Da Cheng Qi Tang（大承气汤）on the vascular permeability. ¹²⁵I-serum albumin was injected into abdominal cavity or tail vein of experimental animals and they were killed by luxation of cervical vertebra 30 minutes after injection,then the washed solution from abdominal cavity was used to determine the radioactivity.At the same time the effect of the drug on the process of exudation and absorption of vascular permeability was investigated.The results showed that the vascular permeability of inflammation groups was higher than that of the normal group.The effects of Da Cheng Qi Tang on vascular permeability varied with different pathological models:after medication,the permeability （exudation）decreased in the model of armpit abscess,but increased（absorption）（0.13±0.01）in the model of peritonitis（39.44±2.79）,which showed a significant difference compared with the control groups（0.33±0.66 and 48.31±1.28）.In the same model the effects varied with the process of permeabihty,inflammatory course and level.The exudation of peritonitis group was reduced while the absorption was enhanced after medication,showing significant difference compared with the control group（P<0.001）.No effect was noted in the 3-hour experiment group or 24-hour mild inflammation group.Biphasic effect failed to appear in animals anaesthetized with Pemobarbital.

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