中医阴阳的实验性研究(Ⅱ)  附子、肉桂和六味地黄方对高血压大鼠尿醛固酮等的影响

Experimental Research of Yin-Yang Theory in TCM(Ⅱ)Effect of Mankshood,Bark of Chinese Cassia Tree and Liu Wei Di Huang Fang on Urinary Aldosterone etc.in Renovascular Hypertensive Rats

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DOI：

中文关键词: 高血压大鼠六味地黄方醛固酮肾血管性高血压附子实验性研究血管紧张素助阳药血压水平肉桂

英文关键词:

基金项目:

作者	单位
顾德官	上海市高血压研究所
邝安堃	上海市高血压研究所
顾天华	上海市高血压研究所
宋代军	上海市高血压研究所
陈贤妙	上海市高血压研究所

摘要点击次数: 1912

全文下载次数: 1198

中文摘要:

本文资料证实助阳药附子或附子加肉桂(附桂)明显地增高二肾一夹型高血压大鼠的血压。对该模型 PRA、ACE 和 UKa 浓度的影响,助阳药附子或附桂与滋阴药六味地黄方之间无有意义的区别。但助阳药附子却明显地增高 UA 的排出(P<0.001),六味地黄方则不改变它的排出。这和对血压的观察一样,提示二肾一夹型高血压大鼠可能为中医的"阴虚"模型。

英文摘要:

This paper confirms that mankshood used singly or in combination with bark of Chinese cassia tree as Yang-tonifying drugs could obviously increase the blood pressure in two-kidney one-clip Goldblatt hypertensive rats,but Liu Wei Di Huang Fang(rehmannia compound Radix Rehmanniae,Fructus Corni,Rhizoma Dioscoreae,Rhizoma Alismatis,Cortex Moutan Radicis and Poria)of Yin-nourishing drug did not alter the blood pressure in them.On the other hand,the plasma renin activity(PRA), angiotensin I converting enzyme(ACE),urinary kallikrein(UKa)and urinary aldosterone(UA)were determined.Ten weeks after operation(four weeks after giving the drug)the effect ofmankshood and Liu Wei Di Huang Fang on PRA was nearly the same,and their effect on ACE and UKa showed no significant change either.However,the level ofaldosterone excretion in these rats was higher than that of normotensive rats(P<0.01).mankshood further increased UA excretion in the hypertensive rats(P <0.001),but Liu Wei Di Huang Fang made no change in UA excretion. Just as the action of mankshood as a Yang-tonifying drug on the blood pressure,the action of mankshood on aldosterone might suggest that two-kidney one-clip Goldblatt hypertensive rats might be a Yin-Xu(Yin-deficiency)model of TCM.

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