中医阴阳的实验性研究(Ⅲ)  附子、肉桂和六味地黄方对高血压大鼠脑组织脑啡肽的影响

Experimental Research of Yin-Yang Theory in TCM(Ⅲ)—Effect of Mankshood, Bark of Chinese Cassia Tree and Liu Wei Di Huang Fang on Enkephalin of Brain Tissue in Renovascular.Hypertensive Rats

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中文关键词: 肾血管性高血压大鼠六味地黄方大鼠脑组织脑啡肽纹状体附子下丘脑助阳药正常血压滋阴药

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作者	单位
顾德官	上海市高血压研究所
邝安堃	上海市高血压研究所
邱喜盛	上海市高血压研究所
顾天华	上海市高血压研究所
茅守玉	上海市高血压研究所

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中文摘要:

在实验中观察到二肾一夹型高血压大鼠的脑组织脑啡肽含量明显低于正常血压大鼠。发现助阳药附子使该型大鼠的脑组织脑啡肽明显降低,但滋阴药六味地黄方却使脑啡肽向正常血压大鼠的值回升。结果说明,中医的助阳药和滋阴药对该模型的脑啡肽有相反的作用,即前者使其恶化而后者起有益的作用。这提示二肾一夹型高血压大鼠可能属中医的"阴虚"模型。

英文摘要:

The mankshood(root)and bark of Chinese cassia tree are Chinese materia medica of Yang-tonifying drug and Liu Wei Di Huang Fang(rehmannia compound Radix Rehmannia,Fructus Corni,Rhizoma Dioscoreae,Rhizoma Alismatis,Cortex Moutan Radicis and Poria)is Chinese materia medica Yin-nourishing drug.In our experiment we have found that the levels of both M-enkephalin(MEK)and L-enkephalin(LEK)of the brain-trunk,hypothalamus and striatum in the two-kidney Goldblatt hypertensive rats,were obviously lower than those in the normotensive rats.The mankshood increased the arterial blood pressure and decreased the levels of both MEK and LEK in the hypertensive rats.However,Liu Wei Di Huang Fang did not lower the blood pressure,while the levels of MEK and LEK recovered nearly to normal level in the hypertensive rats.Generally the sympathetic system of two-kidney hypertensive rats is over-active and mankshood with adrenalin-like activity promotes this over-activity.This experiment showed that the deficiency of enkephalin could increase the sympathetic activity,whereas the rise of enkephalin decreases it.Hence the recovery of the enkephalin level to near normal from Liu Wei Di Huang Fang’s action has contributed to decrease the sympathetic activity in the two-kidney Goldblatt hypertensive rats.The fact that TCM Yang drug and Yin drug had opposite action on the level of enkephalin of the brain tissue in the two- kidney Goldblatt hypertensive rats with the Yang drug having deteriorative and the Yin drug,beneficial action, suggested that this model represents the Yin-Xu(Yin deficiency)model.This result adds to our understanding of Yin-Yang theory in TCM.

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