| 张璧姿,陈振中.蒲黄对高脂血症降脂作用的临床及实验研究[J].中国中西医结合杂志,1985,(3):141-144,130 |
| 蒲黄对高脂血症降脂作用的临床及实验研究 |
| Clinical and’Experimental Research of Typba Angustata on Hyperlipoidemia |
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| DOI： |
| 中文关键词: 高脂血症 降脂作用 有效部位 实验研究 安妥明 蒲黄 安慰剂 显著差异 降脂药物 对照观察 |
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| 摘要点击次数: 1276 |
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| 中文摘要: |
| 本文采用"安慰剂"、"安妥明"对照的方法,肯定了中药蒲黄及其有效部位 A3对330例高脂血症患者的降脂作用;动物实验与临床结果基本一致,有效部位的降脂效应得到临床和药理的证实;无明显毒副作用,提示蒲黄可作为一个较好的降脂新药。 |
| 英文摘要: |
| Typha angustata（TA）,a commonly-used Chinese herbal drug and the chief ingredient in the ancient prescription—Shi Xiao powder（失笑散）has the action of activating blood flow and causing hemostasis.Since 1975, we have studied the effect of TA on 330 patients with Hyperlipoidemia arranged at random with control group （administered with placebo and clofibrate）.The results showed:（1）TA and its fat-soluble extract（A3）can decrease triglyceride and cholesterol in the serum.Striking difference was observed between the TA,A3 group and placebo group（P<0.05）.Yet no significant difference was noticed between the TA,A3 group and clofibrate group（P>0.05）. （2）In the course of treatment,TA and A3 showed no toxic side effect and thusproved better than clofibrate.In the animal experiments,A3 not only decreased triglyceride and cholesterol but also increased high density lipoprotein cholesterol level.The experiments of acute and subacute toxicity showed that A3 has no toxicity,which accords completely with the results of clinical observation. |
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