| 朱伯卿,戴瑞鸿,尤钰,殷模英,金椿,王受益,吕国庆,钱重光,刘月英,徐稚民,池翠萍,蒋丽瑾,孙瑰丽.附子治疗虚证病窦综合征的疗效及机理探讨[J].中国中西医结合杂志,1985,(4):219-222,195 |
| 附子治疗虚证病窦综合征的疗效及机理探讨 |
| Evaluation of Clinical Efficacy of Aconitic Injection in Asthenia Patients Suffering from Sick Sinus Syndrome and Its Mechanism |
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| DOI： |
| 中文关键词: 病窦综合征 附子 神经阻滞 经食管心房调搏 治疗后 显著差异 窦房结功能 虚证 注射液 治疗前后 |
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| 中文摘要: |
| 13例虚证病窦综合征患者通过经食管心房调搏及心脏收缩时间间期等测定,证实附子注射液能明显缩短窦房结恢复时间及明显减小PEP/LVET,提示附子确能提高与改善窦房结功能与心功能,尤对阳虚病例效果显著。附子温阳的机理可能是通过兴奋β肾上腺素能受体,促进钠、钙离子内流等多种作用途径。 |
| 英文摘要: |
| Clinical efficacy and the mechanism of Aconitic injection were evaluated in 13 asthenia patients suffering from sick sinus syndrome.Aconitic intravenous injection was administrated at a dose of 12g per day for 2 to 4 weeks. Clinical symptoms of both cardiac and cerebral ischemia were found improved after therapy,and the severity of arrhythmias was relieved as well by EKG monitoring.The heart rate at rest increased from 51±5 to 56±4 beats/min (P<0.05),whereas during exercise,it increased from 60±7 to 74±7 beats/min(P<0.001). The sinus node recovery time(SNRT)was assessed by transesophageal atrial pacing.The maximum SNRT was significantly shortened from 3,138±1,139 ms to 2,149±988 ms(P<0.05)after therapy.The maximum SNRT after sympathetic and parasympathetic blocking was also significantly shortened from 3,352±1,196 ms to 2,135±947 ms (P<0.01).The shortening value of patients with Yang deficiency was significantly larger than those with Ying deficiency (648±408 ms vs 310±159 ms,P<0.001). The value of PEP/LVET was found decreased from 0.320±0.026 to 0.297±0.024(P<0.001)by the measurement of STI.The results indicate that the so called warming Yang Chinese herb Aconitum appears to improve the functions of sinus node and cardiac performance in asthenia patients with sick sinus syndrome,and the stimulation of beta adrenergic receptor was considered one of the mechanisms of action. |
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