| 汪钟,杜金香,朱国强,游美梅.毛冬青甲素对血小板功能和形态的影响[J].中国中西医结合杂志,1985,(4):232-234,257,197 |
| 毛冬青甲素对血小板功能和形态的影响 |
| The Effect of Ilexonin A on Platelet Function and Uitrastructure |
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| DOI： |
| 中文关键词: 毛冬青甲素 血小板聚集 血小板功能 静脉注射 胶原 释放反应 正常大鼠 血小板超微结构 药物抑制 聚集作用 |
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| 中文摘要: |
| 本文观察到毛冬青甲素体外给药,能抑制 ADP、胶原诱导的人、兔血小板聚集和5羟色胺释放,剂量与效应相关。药物抑制 ADP 诱导的聚集和释放反应较强,给大鼠体内给药,也明显抑制血小板聚集。电镜下超微结构研究表明,正常大鼠血小板呈椭圆形,颗粒清晰可见,给注射盐水大鼠的 PRP 中加入 ADP,血小板从分散变为明显聚集,甚至互相融合,但颗粒仍存在.若给静脉注射毛冬青甲素大鼠的 PRP 中加入 ADP,则血小板的超微结构除偶见伪足形成外其余与正常大鼠无明显差别。 |
| 英文摘要: |
| We investigated the effect of Ilexonin A on rabbit and human platelet function in vitro and rat platelet aggregation in vivo.Ilexonin A inhibited the aggregation and serotonin release of rabbit and human platelets induced by either ADP or collagen in a dose-dependent manner in vitro.The platelet aggregation was inhibited up to 100% and 40% respectively when ADP indution of PRP was performed 5 and 30 minutes after administration of the drug,however the inhibitory effect almost disappeared within 1 hour.Ultrastructure under electronmicroscope indicated the platelets of normal rats were oval in shape,the granules were clearly visible.After addition of ADP to PRP of rats injected with normal saline,the dispersed platelets aggregated but the granules were still present.When ADP was added to PRP of rats injected with Ilexonin A intravenously,the platelets were not significantly different from normal except occasionally pseudopod formation. |
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