雷公藤治疗类风湿性关节炎165例疗效分析

作者	单位
严碧玉	第一军医大学中医系内科学教研室
翟国江	第一军医大学中医系内科学教研室
蒋民主	第一军医大学中医系内科学教研室

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中文摘要:

用雷公藤治疗类风湿性关节炎165例,平均服药时间为4.6个月。治疗后关节症状和体征明显改善,晨僵时间缩短,握力增加,20m 步行时间多恢复正常,实验室检查明显好转。总有效率为96.4%。

英文摘要:

The therapeutic effects of Tripterygium wilfordii Hook(TW)administered orally on 165 patients(45 male,120 female)with rheumatoid arthritis are described.The average duration of treatment was 4.6 months.Symptoms and signs of arthritis were obvious prior to the treatment but were relieved satisfactorily after treatment.Of the 165 patients treated,16 were clinically cured(10.9%),95 showed marked improvement(57.6%)and 46(27.9%)had some improvement too.Total efficacy of the drug was 94.4%. These results showed that TW may well relieve the morning stiffness,shorten the time for walking 20M,and increase the grip strength.In most cases,erythrocyte sedimentation rate declined evidently,the hemoglobin content rose,rheumatoid factors became negative,serum IgG,IgM and c-globulin levels returned to normal. The main curative effects of TW on rheumatoid arthritis lie in anti-inflammation and immunosuppression, the former helps to lower the permeability of capillaries and the latter is realized by inhibition of immune organs such as thymus etc.TW has similar immunosuppressive effect(action)as that of steroid,but does not influence the normal secretion as that of steroid in the body.

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