快速检索:        
    
在线办公系统
在线期刊
下载专区
排行榜
友情链接
扫描微信二维码,获取更多信息
王玉良,巴彦坤.川芎嗪对心血管组织的药理和电生理作用——一种新的“钙拮抗剂”?[J].中国中西医结合杂志,1985,(5):291-294,320,260
川芎嗪对心血管组织的药理和电生理作用——一种新的“钙拮抗剂”?
Pharmacodynamic and Eiectrophysiological Studies of Ligustrazini on Cardiovascular Tissues—A New Calcium Antagonist?
免费下载全文  查看/发表评论  下载PDF阅读器
  
DOI:
中文关键词:  钙拮抗剂  乳头肌  动作电位  钙离子拮抗剂  异搏停  川芎嗪  希氏束电图  变导作用  心血管药理  川芍
英文关键词:
基金项目:
作者单位
王玉良 山西省中医研究所中心实验室 
巴彦坤 山西省中医研究所中心实验室 
摘要点击次数: 1505
全文下载次数: 983
中文摘要:
      本文报告采用心血管药理动力学和电生理的方法,在离体组织和细胞水平上对川芎嗪作用的离子机制进行观察,实验结果显示该剂的负肌力效应、负性变频、变导作用,对主动脉平滑肌的松弛效应,均与异搏停的特性非常类似。据此,推测川芎嗪可能系一种新的"钙离子拮抗剂"。
英文摘要:
      The purpose of the present study is to investigate the action of Ligustrazini(Tetramethylpyrazine)on mammalian cardiovascular system by using pharmacodynamical and cellular electrophysiological techniques in combination. The preliminary results show that the specific effects of Ligustrazini strikingly resemble those of verapamil as a new and most potent"Ca++-antagonistic drug"(slow membrane current inhibitor),both qualitatively and quantitatively. The negative inotropic,negative chrontropic and negative dromotropie effects and the relaxant effect on smooth musculature of aorta could be reversed by increasing the extracellular calcium concentration,but b-adrenergic receptor agonists did not influence these results. Accordingly,it can be concluded that Ligustrazini acts as a"calcium antagonist".
关闭