蒲黄的引产作用及一般药理实验

中药蒲黄注射液对豚鼠、小白鼠中期引产有明显的效果,腹腔注射最低有效量为2～3g/kg 体重。其一般药理实验表明:急性毒性实验 LD₅₀为35.57g/kg 体重,对豚鼠有过敏现象,缩短凝血时间,减少红、白细胞总数。对家兔有溶血作用。短暂的抑制蛙离体心脏和降低家兔血压。对豚鼠离体子宫和家兔在位子宫有兴奋作用,但抗生育作用机制有待进一步阐明。

英文摘要:

The labor-induction effect of injectio typha was comfirmed in 14 pregnant albino mice and 16 pregnant guinea pigs.The effective dosage was 2-3g/kg.Results of common pharmacological experiments of injectio typha are as follows:The LD₅₀is 35.57g/kg.The effective dosage of injectio typha in labor-induction experiments was 12-18 times lower than that of the LD₅₀dosage in mice,therefore it is rather safe. Intraperitoneal injection of injectio typha shows hypersensitivity.It causes haemolytic effect,shortens the time of blood coagulation and thus promotes the said process.It decreases total count of both red and white cells,and has a temporal inhibitory effect on the excised toad heart and also decreases the blood pressure of rabbits.Injectio typha has an excitatory effect on the uteri of rabbits both in vitro and vivo,smaller dosage has the effect of enhancing the contraction of uteri,but with larger dosage,the excitatory effect is so obvious that irregular and spasmatic contraction is observed.

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