| 邹樟,程道新,王一琴.青蒿素对感染鼠疟小鼠溶血空斑和玫瑰花形成细胞的影响[J].中国中西医结合杂志,1985,(9):563-564,557,517 |
| 青蒿素对感染鼠疟小鼠溶血空斑和玫瑰花形成细胞的影响 |
| The Effect of Qinghaosu(青蒿素)nn PFC and RFC of mice Infected with Piasmodium Berghei |
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| 中文关键词: 疟原虫感染 正常小鼠 玫瑰花 感染小鼠 青蒿素 小鼠腹腔巨噬细胞 免疫反应 溶血空斑形成细胞 红细胞悬液 治疗 |
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| 中文摘要: |
| 通过青蒿素对感染疟原虫小鼠溶血空斑形成细胞(PFC)和玫瑰花形成细胞(RFC)影响的实验观察表明,感染贝氏疟原虫的小鼠,在血虫率较高时,PFC、RFC 反应受到严重抑制。此时用青蒿素治疗(每天300mg/kg×7天),杀灭血中原虫后测定 PFC、RFC,反应逐渐恢复;以氯喹治疗组为对照,两组间无明显差异。并对疟原虫感染后小鼠腹腔巨噬细胞在免疫反应中起的作用,做了初步的探讨。 |
| 英文摘要: |
| Arteannuin,a new antimalaria,was separated from Herba Artemisiae Qinghao,a traditional Chinese drug. Arteannuin kills parasites by interfering with their metabolic processes,and may contribute to increasing immunity of the host.Phagocytosis of macrophages was examined and the phagocytic capacity was found to have increased noticeably,the RFC and PFC of infected mice and normal mice were examined too.When the mice were infected with P.berghei,the PFC and R FC decreased.Arteannuin was used to cure the infected for 7 days,the PFC and RFC were studied daily after discontinuation of the drug,the PFC and RFC increased continuously,but slowly.On the 21st day,the PFC and RFC increased to 28% and 32%,the level of normal mice.The results were similar to those obtained with Chloroquine.The macrophages taken from peritoneal exudate of the normal mice.were injected into the infected mice,and the PFC and RFC were examined;the results showed no difference. |
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