| 成柏华,朱顺和,张曼莉,李忠华,俞国瑞.槲寄生防治急性心肌梗塞改善心肌氧耗的实验观察[J].中国中西医结合杂志,1985,(9):565-566,533,517 |
| 槲寄生防治急性心肌梗塞改善心肌氧耗的实验观察 |
| An Experimental Observation on Preventive and Curative Effect of Viscum Coloratum on Acute Myocardial Infarction by Improving the Myocardial Oxygen Consumption |
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| DOI： |
| 中文关键词: 急性心肌梗塞 槲寄生 梗塞区 心肌梗塞后 冠状动脉 防治 缺血心肌 实验观察 自身对照 心肌缺血 |
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| 中文摘要: |
| 在28只家兔实验性心肌梗塞模型中直接观察到槲寄生对实验性心肌梗塞后的缺血心肌有明显降低耗氧代谢的作用,不论自身对照或组间对照均具显著意义(P<0.05)。其作用机理,可能为槲寄生改善了冠状动脉的侧枝循环,或者槲寄生能降低心肌 cAMP 的含量而直接对抗了β-受体的兴奋,从而减缓了心肌缺血的交感反射所致的耗氧代谢增加 |
| 英文摘要: |
| The beneficial effect of Viscum coloratura on ischemic myocardium of 28 rabbits is reported in this paper.After being treated with Viscnm coloratum,the infarcted area showed no change of myocardial oxygen consumption (P>0.05)statistically as compared with the uninfarcted area.If not treated with Viscum coloratum,there would be a significant increase of myocardial oxygen consumption in infarcted myocardial area as compared with the uninfarcted myocardium(P<0.05). While comparison is made among different groups,significant difference(P<0.05)was also observed.The mechanism of these results,according to the author,might lie in the fact that Viscum coloratum could improve coronary collateral circulation,and thus increase the blood oxygen supply.On the other hand,it was verified that Viscum coloratura could decrease the cAMP level in ischemia myocardium significantly(P<0.05).So Viscum coloratura would directly counteract the excitement of β-receptor causing a remission of oxygen consumption enhanced by sympathetic reflex during the ischemic myocardium. |
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