益气活血法治疗冠心病心绞痛的临床及实验研究

作者	单位
陈俊杰	北京中医学院东直门医院气血研究室
廖家桢	北京中医学院东直门医院气血研究室
武泽民	北京中医学院东直门医院气血研究室
赵岚晏	北京中医学院东直门医院气血研究室
于维杰	北京中医学院东直门医院气血研究室
郭维琴	北京中医学院东直门医院气血研究室
赵悦如	北京中医学院东直门医院气血研究室
高杰	北京中医学院东直门医院气血研究室
吴鼎昌	北京中医学院东直门医院气血研究室
赵忠印	北京中医学院东直门医院气血研究室
刘娴芳	北京中医学院东直门医院基础研究室
秦腊梅	北京中医学院东直门医院基础研究室
宋崇顺	北京中医学院东直门医院基础研究室
吕小燕	北京中医学院东直门医院基础研究室
任映	北京中医学院东直门医院基础研究室
刘书桐	北京中医学院东直门医院基础研究室

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中文摘要:

本研究采用单盲法,在同一患者自身前后对照气血注射液及葡萄糖液对心绞痛的疗效。结果说明心绞痛症状及心电图的疗效,气血注射液均十分明显优于葡萄糖液,并经次极量活动平板运动试验的客观验证,气血注射液确可提高冠心病患者运动耐受量,而葡萄糖液则无此作用,证明气血注射液治疗心绞痛的疗效是肯定的。该药并明显改善左心功能及心排量,改善血液的流变性及微循环,增加心肌营养血流量,对心肌细胞膜钠-钾 ATP 酶的活性有一定的抑制作用。

英文摘要:

Therapeutic effects of Qixue Injection(气血注射液 QXI,consisting of three Chinese herbal medicines:Radix Ginseng,Radix Astragali,Radix Angelicae Sinensis)and placebo(10% dextrose)were compared in 32 patients with stable effort-induced angina by means of single-blind method.The results are as follows:(1)1 hr.after 20 ml QXI i.v., the treadmill excercise endurance increased from pre-treatment level of 368.00±32.75((?)±SE)/sec to 528.11 ±63.43/sec post-QXI(P<0.01),the ST segment depression was reduced from 0.11±0.007 mV pre-treatment to 0.082±0.008 mV(P<0.05),the PEPI.PEP/LVET ratio were reduced,the LVETI,SV,CO,△D% and EF were increased significantly,which suggested that the left ventricular performance was strengthened;(2) QXI 20 mlin 10% dextrose 250 ml intravenous effusion daily for 2 weeks,after that the treadmill excercise endurance increased from 319.45±42.12 sec to 583.20±62.59 sec(P<0.001),the ST segment depression was reduced from 0.14±0.016 mV to 0.09±0.014 mV(P<0.01),the left ventricular performance was more improved than that in cases treated with single dose of 20 ml intravenously.The rheologic parameters such as whole blood viscosity,plasma viscosity and erythrocyte electrophoretic time as well as the microcirculation in nail improved too after treatment with QXI for 2 weeks;(3)18 of the 32 patients were selected randomly for placebo control,whom the placebo solution(10% dextrose)250 ml daily were given intravenously for 2 weeks,the results showed no effect whatsoever.The experiments on rats showed that[Na~+ -K~+]ATPase activity could be partly inhibited and the volume of nutritious blood supply to myocardiurn was increased by QXI.

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