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冯立明,李彩华,潘华珍,张之南.阿魏酸钠对补体溶血的影响[J].中国中西医结合杂志,1985,(11):681-683,645
阿魏酸钠对补体溶血的影响
The Effect of Sodium Ferulate on Complement-Activated Hemolysis
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DOI:
中文关键词:  阿魏酸钠  红细胞膜  红细胞变形性  补体激活  阵发性睡眠性血红蛋白尿症  溶血试验  溶血度  凝胶电泳  保温  加药
英文关键词:
基金项目:
作者单位
冯立明 北京协和医科大学 
李彩华 北京协和医科大学 
潘华珍 北京协和医科大学 
张之南 北京协和医科大学 
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中文摘要:
      本文以正常人及阵发性睡眠性血红蛋白尿症(PNH)患者的红细胞为对象,观察阿魏酸钠对补体溶血的影响及其机理。结果说明阿魏酸钠可明显降低补体溶血,抑制补体3b(C3b)与红细胞膜的结合;对补体激活及红细胞变形性无影响。
英文摘要:
      Sodium Ferulate(SF)is one of the ingredients derived from Radix Angelicae Sinensis and Rhizoma Ligustici Chuanxing.Red blood cells from normal persons or paroxysmal nocturnal hemoglobinuria(PNH)patients were incubated with SF and the effect of SF on Cobra Venom Factor(CoF)hemolysis test,activation of complement(C3), the binding of C3bwith red blood cell membrane and red cell deformability was observed.The result revealed that SF could definitely reduce the hemolysis induced by CoF and the binding of C3bto red cell membrane was decreased. but no influence on the activation of complement through alternate pathway or effect on red cell deformability was observed.The mechanism of action was briefly discussed.
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