草问荆提取物抗心肌缺血的药理研究

作者	单位
常福久	黑龙江中医学院药理教研室
苏云明	黑龙江中医学院药理教研室
华英圣	黑龙江中医学院药理教研室
周敏	黑龙江中医学院药理教研室

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中文摘要:

给小鼠腹腔注射草问荆提取物10～15g/kg,能提高小鼠在低压和常压条件下耐缺氧能力,增强预先投与异丙肾上腺素所致的耐缺氧能力,使小鼠耗氧率较对照组降低32.8%。心肌⁸⁶Rb 摄取率较对照组分别降低8.2%,26.4%,能对抗异丙肾上腺素所致心肌与血浆中 cAMP 含量增高。静脉注射1.5～3.0g/kg,对垂体后叶素所致的 ECG 的 S-T 段和 T 波增高,心率减慢,都有显著的对抗作用。对心电图影响,使 RR、PQ、QT 和 QRS 间期较给药前显著延长。

英文摘要:

The extract isolated from the herb of Equisetum pratense was found to be effective on cardiovascular system. The ip.with 10-15 g/kg of this extract prolonged the survival time of mice under normobaric and hypobaric hypoxia significantly,increased notably the tolerance towards myocardiae hypoxia induced by isoproterenol in mice（under hypobaric and normobaric condition）and slowed down the oxygen consumption rate by 32.8% compared with the control group.When this extract was given intraperitoneally at dosage of 10 g/kg and 15 g/kg,the percentage of myocardial uptake of ⁸⁶Rb,as well as propranolol,decreased by 8.2% and 26.4% as compared with control group respectively.This indicates that myocardial blood flow was not augmented.After the ip.with 15 g/kg of this extract in mice,the increase of the cAMP content of myocardium and plasma by isoproterenol was checked significantly. Experimental myocardial ischemia was reduced by iv.1.5-3.0 g/kg of this extract as indicated by improvement ofECG.A widening of the QRS complex and a prolongation of the RR,PQ,and QT intervals on ECG was observed. The toxic dose and minimal lethal doses of this extract given intravenously to guinea pigs were found to be 24.4 ±1.95 g/kg and 31.3±1.7 g/kg respectively.

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