| 潘国宗,孙钢,陈敏章.白芍对大鼠离体胰腺腺泡淀粉酶活力及分泌的影响[J].中国中西医结合杂志,1986,(2):100-102,69 |
| 白芍对大鼠离体胰腺腺泡淀粉酶活力及分泌的影响 |
| Effect of Paeonia Lactiflora on Amylase Activity and Amylase Release from Pancreatic Acini in Rats |
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| DOI： |
| 中文关键词: 胰腺腺泡细胞 淀粉酶活力 白芍 酶分泌 胰淀粉酶 促胰液素 大鼠 急性胰腺炎 中西医结合治疗 水提液 |
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| 摘要点击次数: 1523 |
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| 中文摘要: |
| 高浓度白芍水提液对大鼠胰淀粉酶活力有明显抑制作用;浓度≤16mg/ml时不影响酶活力,但可使八肽胆囊收缩素(CCK-OP)诱导胰腺腺泡分泌淀粉酶的效价降低10倍,却不影响促胰液素刺激的酶分泌。这一选择性的拮抗作用说明白芍水溶性成分中可能有某种活性物质,可拮抗胰腺腺泡细胞膜上的 CCK 受体。这也许是白芍在清胰汤中对胰腺炎产生治疗作用的原因之一,但对其有效成分尚需进一步研究。 |
| 英文摘要: |
| The root of Paeonia lactiflora(PL)is an important component in the decoction of TCM for the treatment of acute pancreatitis.In the present study,we examined the effect of the water soluble extract of PL on amylase activity and amylase release induced by cholecystokinin octapeptide(CCK-OP)or secretin using in vitro preparation of dispersed pancreatic acini prepared from rat pancreas. Results from the study indicated that:(1)At a high concentration,the drug prominently inhibited pancreatic amylase activity,but it had no effect on this activity at low concentrations(≤16mg/ml). (2)PL at a concentration of 16 mg/ml could modify the action of CCK-OP and produced a 10-fold decrease in its potency in stimulating amylase release from pancreatic acini,but it did not affect amylase secretion induced by secretin.(3)Because of this selective effect of PL in inhibiting the action of CCK on amylase secretion,we assume that certain components of the drug might possess the ability of antagonizing the action of CCK at the cell receptor level. The result also indicates that the above mentioned action of PL may be related to its therapeutic effect in the treatment of acute pancreatitis. |
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