大黄的降温作用及其对中枢神经系统前列腺素E的影响

作者	单位
郭昌燕	北京友谊医院内科
王宝恩	北京友谊医院内科
赵淑颖	北京友谊医院内科
李振甲	中国人民解放军总医院

摘要点击次数: 1875

全文下载次数: 965

中文摘要:

用肺炎双球菌(Ⅱ型)皮内注射制成家兔感染性发热模型,实验组给大黄灌服,对照组给自来水。结果证明,大黄能使感染性发热家兔体温下降;并采用第三脑室灌流技术收集灌流液,用放射性免疫技术测定其前列腺素 E(PGE)含量,结果提示,大黄能使感染性发热家兔第三脑室灌流液 PGE 含量降低。作者认为,通腑中药大黄确能荡涤实热,其作用之一是通过影响中枢神经系统内 PGE 而实现。

英文摘要:

Rabbit model of fever was produced by means of subcutaneous innoculation of pneumococci.Decoctior, of Rhubarb(Rheum officinale)was given orally to the experiment group(n=17)and tap water to the control(n=17).Anal temperature was markedly reduced in the Rhubarb group and significant difference vs the control group was observed(P<0.001).For comparison,anal temperature was measured in 10 normal rabbits before and after Rhubarb administration,but no marked change was recorded(P>0.2) Third ventricular intubation and irrigation was carried out in 5 rabbits.Irrigation fluid of the third ventricle was collected during the stage of normal temperature,at the peak of fever and when the temperature was lowered by Rhubarb.Prostaglandin E was detected with RIA in each of the three portions of the irrigated CSF.The results showed that PGE level was raised during fever and decreased after Rhubarb administration(4.92±2.2 to 1.5±1.2ng/ml,P<0.001).In 17 normal rabbits,the same happened after treatment with Rhubarb(2.3±1.8 to 1.9±1.3ng/ml,P<0.01).Irrigation of CSF without medication had no significant influence to the PGE level either in febrile rabbits or in normal one (P>0.05). The above data reveal that Rhubarb can reduce the infective fever in rabbits and its antipyretic effect is closely related to the inhibition of PGE level in CSF,which is the mediator of the temperature center in the central nervous system.

关闭