益气养阴法治疗慢性肾小球肾炎血浆环核苷酸及免疫指标变化的初步观察——附41例临床分析

Preliminary Observation on Cyclic Nucleotide and Other Immunological Parameter Changes in Treating Chronic Glomerulonephritis with "Replenishing Qi and Nourishing Yin"Principle—A Study of 41 Cases

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中文关键词: 慢性肾小球肾炎益气养阴法脾肾气阴两虚细胞免疫显著性治疗后环含量免疫球蛋白正常值免疫功能紊乱

英文关键词:

基金项目:

作者	单位
王钢	南京中医学院附院肾病组
汪君梅	南京中医学院附院肾病组
祁月琴	南京中医学院附院肾病组
申冬珠	南京中医学院附院免疫室
周群	南京中医学院附院免疫室
范欣生	南京中医学院附院免疫室

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中文摘要:

本文报告41例慢性肾小球肾炎脾肾气阴两虚证患者,治疗前测定:血浆cAMP、cGMP 含量升高,cAMP/cGMP 比值下降;免疫球蛋白(Ig)G 含量降低;细胞免疫Ea 花环含量明显低于正常值,Es 花环含量略高于正常值。经益气养阴法治疗后总有效率90.24%,血浆 cAMP、cGMP、IgG、Es,Ea 花环含量均逐渐恢复正常,治疗前后对比,差异均有非常显著性意义(P<0.01)。提示:慢性肾小球肾炎脾肾气阴两虚证的物质基础,可能与细胞内环核苷酸双向控制系统失调、免疫功能紊乱有关;益气养阴法治疗慢性肾小球肾炎脾肾气阴两虚证,可能有双向调节细胞内环核苷酸及免疫功能的作用。

英文摘要:

In recent years,the incidence of chronic glomerulonephritis with deficiency of both Qi(vital energy)and Yin (vital essence)seems to be higher than before,and it almost constitutes 30～35% of the patients.In order to explore the material base of this symptom-complex and the mechanism of"replenishing Qi and nourishing Yin",plasma cAMP,cGMP,serum IgG,IgA,IgM as well as Ea,Es rosette were inwestigated before and after treatment in hospitalized patients. Before treatment,plasma cAMP and cGMP levels were obviously higher than normal,while the ratio of cAMP/cGMP significantly lower,P<0.01;serum IgG level was much lower than the normal,however,no change of IgA and IgM occurred;Ea rosette level was markedly under the normal,and Es level,slightly higher than it. The effective rate of this therapy was 90.24%.After treatment,all of the plasma cAMP,cGMP,IgG,Ea and Es rosette levels normalized gradually;the difference of pre-and post-treatment was significant(P<0.01). This suggests that the substantial base of chronic glomerulonephritis with deficiency of both Qi and Yin might be closely related to the dysfunction of bi-directional regulating system and the disturbance of immunological function.The mechanism of this therapy probably is due to its regulating function in modulating the intracellular cyclo-nucleotide and immunological disturbances.

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