中医阴阳的实验性研究(Ⅴ)附子、肉桂对肾上腺再生高血压大鼠的作用

Experimental Research on Yin-Yang of TCM (V)Effect of Aconitum Carmichaeli and Cinnamomum Cassia on Hypertensive Rats Induced by Adrenal Regeneration

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DOI：

中文关键词: 肾血管性高血压大鼠高血压性肾上腺肉桂纹状体附子助阳药醛固酮下丘脑高血压模型

英文关键词:

基金项目:

作者	单位
邝安堃	上海市高血压研究所
顾德官	上海市高血压研究所
宋代军	上海市高血压研究所
邱喜盛	上海市高血压研究所
黄申	上海市高血压研究所

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中文摘要:

用助阳药附子、肉桂对肾上腺再生高血压模型的实验表明,附桂二味或肉桂单味均明显减低高血压大鼠的血压(P<0.01)和尿醛固酮排出(P<0.001)。肉桂显著增高纹状体和下丘脑的脑啡肽含量(P<0.001)。附子、肉桂明显改善胸主动脉内膜的高血压性损害。结果说明助阳药附子、肉桂对肾上腺再生高血压呈一定治疗效应,支持该模型可能属中医"阳虚"模型的观点。

英文摘要:

The experiment showed that Aconitum carmichaeli and Cinnamomum cassia markedly reduced the blood pressure(P<0.01)and urinary aldosterone(UA,P<0.001)in the hypertensive rats induced by adrenal regeneration.The level of L-enkephalin(LEK)in brain tissue was louver in the hypertensive rats than in the normal rats,while the Cinnamomum cassia obviously increased it(P<0.001).The etectron microcopy of aortic intima in rats showed that endothelial cells and subendothelial layer of the lesion caused by hypertension were improved by using these two medicinal herbs.These Yang tonifying drugs might cure hypertensive rats induced by adrenal regeneration,it suggested that this animal model possibly belongs to the Yang deficiency model of TCM,also supported the hypothesis that the Yin or Yang tonifying drug may exert allopathie effect on the Yin or Yang deficiency model of hypertensive rats,which conforms to the theory of TCM.Hence,the right choice of drug can cure Yin or Yang deficiency both in man or animal models,as shown in this and our preceding papers.

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