胃粘膜组织化学染色和环核苷酸测定研究肠化生、癌变、脾虚证与cAMP间关系

A Study of Relationship among Intestinal Metaplasia,Gastric Carcinoma and Spleen Deficiency Syndrome by the Histochemical Staining of Gastric Mucosa and the Determination of Its cAMP and cGMP

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DOI：

中文关键词: 胃粘膜肠化生脾虚证胃病组织化学染色肠型胃癌脾虚气滞证不完全性脾气虚证显著差异慢性胃炎癌变

英文关键词:

基金项目:

作者	单位
尹光耀	无锡市第三人民医院
唐静芬	无锡市第三人民医院
杨柏岩	无锡市第三人民医院
朱明月	无锡市第三人民医院
薛素华	无锡市第三人民医院
虞佩英	无锡市第三人民医院
周奚钟	无锡市第三人民医院
俞宪民	无锡市第三人民医院

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中文摘要:

通过组织化学染色和放射免疫方法测定,研究25例脾虚证慢性胃病患者胃粘膜肠化生分型及胃粘膜与血浆环核苷酸含量测定,发现肠化生率,结肠型肠化生率和不完全性结肠型肠化生率在良性胃病与胃癌间,在脾气虚证与脾虚气滞证间,均有显著差异,P<0.05～0.001。提示 cAMP 量变可能是引起脾虚证、胃粘膜肠化生和胃癌的物质基础,不完全性结肠型肠化生可能是引起"肠型胃癌"的重要病理基础,临床上应高度警惕脾虚气滞证胃病伴有不完全性结肠型肠化生和血浆 cAMP 降低患者的癌变倾向。

英文摘要:

Four different kinds of gastric change of intestinal metaplasia,gastric mucosa and plasma cAMP and cGMP level were investigated with histochemical and radioimmuno-assay in 25 cases of chronic gastropathy manifested as spleen deficiency syndrome(脾虚证).The rate of intestinal metaplasia,rate of intestinal metaplasia of colonic and incomplete colonic type and stomach carcinoma increased in the order of the spleen Qi deficiency(脾气虚)patients and spleen deficiency with Qi stagnation(脾虚气滞)patients;while gastric mucosa and plasma cAMP level decreased in the order of spleen Qi deficiency patients and spleen deficiency with Qi stagnation.patients,and also in the order of complete metaplasia and incomplete metaplasia of small intestinal and colonic types,their statistical differences were significant,P<0.05～0.001. However,no marked changes of cGMP level were observed. All these findings suggest that cAMP level and the intestinal metaplasia of incomplete colonic type were closely related to the spleen deficiency syndrome and gastric carcinoma.The determination of cAMP level and type of intestinal metaplasia of stomach might be of clinical significance in estimating the course of disease and therapeutic efficacy.

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