三杰生肌膏的临床应用及生肌敛口中药外敷作用的实验研究

The paper reports the experience of treating infected wounds with external applicated self-made San Jie Sheng Ji(SJSJ)ointment.Of the 450 cases so treated,443 of them were cured(98.4%),4 cases were basically cured(0.9%)and 3 cases were ineffective(0.7%).No side effect and complication have been observed after the SJSJ ointment treatment for 17.5 days.For fresh wounds,the difference between the SJSJ ointment group and control was significant and for old wounds and chronic ulcer,a more significant difference between these two groups was observed.The composition of prescription,the preparing procedure,the applying method and the indication of the SJSJ ointment were described in detail.The therapeutic mechanism of the ointment was discussed briefly. The 39 Chinese medicinal herbs for tissue growing and wound healing were screened by experimental study in rabbits.It was observed that calamine,margarita,Commiphora myrrha and Boswellia carterii have very significant action(P<0.01),and Crinis carbonisatus,calomel have significant action(P<0.05)in promoting the wound healing whereas the other herbs did not.The concentration of those 6 effective herbs for external application for tissue growing and wound healing were determined as follows:the calamine was 7.5～10 g%,the margarita and Commiphora myrrha were 3～7.5 g%,the Boswellia carterii was 5～7.5 g%, the Crinis carbonisatus was 5～10 g%,and the calomel 3 g%.The synergistic action of the components of compound prescription wore analysed.In general,the effect of compound prescription was the addition or subtraction of the effect of its constituents.By contrast,the effect of paste form of same prescription is markedly better than that of powder form.The influence of decocting time on the effect of paste was also observed.

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