“热毒清”注射液对家兔内毒素DIC生物效应的拮抗作用

作者	单位
林菊生	同济医科大学中西医结合研究所
李鸣真	同济医科大学中西医结合研究所
叶望云	同济医科大学中西医结合研究所

摘要点击次数: 1411

全文下载次数: 1092

中文摘要:

本文通过动物实验,观察了"热毒清"注射液对以大肠杆菌内毒素在家兔体内所制作的 DIC 动物模型病理生理过程的影响。血液学和形态学的结果表明,本制剂对内毒素的 DIC 生物效应具有拮抗作用。文中并就其拮抗机制作了初步探讨。根据体外抗内毒素实验、对枯否氏细胞形态的电镜观察以及其他作者的研究工作,推测可能是通过直接降解内毒素,增强单核—吞噬细胞系统的吞噬功能以及提高 C₈旁路活性而发挥作用的。

英文摘要:

In this paper,an investigation was made on the therapeutic mechanism of heat-clearing and detoxifying Chinese medicinal preparation,Re Du Qing Injection,through animal experiments.According to the principle of generalized Shwartzmart reaction,an animal model of DIC was established in rabbits by injecting the endotoxin of Escherichia Coli,and then the effect of preparation on pathophysiological process of DIC was observed.The hematological results indicated that the control group of normal saline was characterized by changes of DIC,but most of the changes of Re Du Qing treated group were not of statistical significance.Moreover,the morphological results showed that the DIC incidence and its severity were markedly lower in the Re Du Qing treated group than the control.Under electron microscope,the damage to endothelial cells of glomerular capillaries and liver cells in the Re Du Qing treated group was mild in comparison with control.These findings suggested that the preparation possess antagonistic action on the biological activity of endotoxin induced DIC. The mechanism of the antagonistic action was also preliminarily discussed.According to the in vitro experiments,observation on morphology of Kupffer’s cells with electron microscope,and other author’s study,an inference was drawn that the antagonistic action may take place through degrading endotoxin directly,intensifying phagocytosis of MPS and increasing the activity of alternative complement pathway.

关闭