| 王惠成,许青媛,刘旺轩.生脉注射液对家兔体外血栓形成及凝血系统功能的影响[J].中国中西医结合杂志,1986,(7):428-429,390 |
| 生脉注射液对家兔体外血栓形成及凝血系统功能的影响 |
| Experimental Studies on the Mechanism of Inhibition upon Thrombus Formation and Blood Coagulation in Vitro with Sheng-Mai Injection |
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| DOI： |
| 中文关键词: 生脉注射液 体外血栓形成 凝血功能 家兔 血小板功能 内源性凝血系统 血小板聚集 形成时间 纤溶功能 凝血酶时间 |
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| 中文摘要: |
| 本文通过整体清醒动物实验,观察了生脉注射液对正常家兔体外血栓形成、血小板功能、凝血功能以及纤维蛋白原溶解活性的影响。结果表明:(1)生脉注射液有抑制体外血栓形成的作用;(2)抗凝血功能较强,无论对外源性和内源性凝血系统均有明显的抑制作用;(3)对纤溶功能有一定的促进作用。 |
| 英文摘要: |
| Sheng-Mai injection was injected intravenously into eleven rabbits with a dosage of 2ml/kg.Before and two hours after injection,blood was drawn from the rabbit heart directly for the determination of extracorporeal thrombus formation,platelet function,blood coagulation and fibrinolytic activity.The results were as follows:(1)The time of thrombus formation was prolonged(P<0.001).The length of thrombus shortened and its weight decreased.All these changes indicated that the thrombus formation was inhibited by this drug.(2)The platelet count was unchanged,the ADP induced platelet aggregation rate and the ratio of peripheral platelet aggregation were not significantly influenced.(3)The prolonged prothrombin time and prothrombin consumption time indicated that the blood coagulation was inhibited.The effect of the drug may exert on both the intrinsic and extrinsic coagulaion system.(4)The plasma fibrinogen was decreased, but there were no significant changes in the thrombin and the euglobulinolysis time.All these results suggest that the Sheng-Mai injection possesses an inhibitory function on extracorporeal thrombus formation and blood coagulation,it exerts a weak promotion to the fibrinolytic function,but does not influence the platelet counts and their functions. |
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