中医中药治疗慢性肾功能衰竭疗效观察

This paper reports the comparative observation of short term effect,the trend of disease progress and the survival period in uremic patients with plasma creatinine over 5mg%.Patients were randomly divided into two groups,group A and B,since 1981.Patients in group A were treated with"Tong Fu Xie Zhuo"(通腑泄浊,purgating to expel the wetness-evil);while in group B,patients were treated with"Bian Zheng Lun Zhi"(辨证论治,treat the patient according to syndrome differentiation)and"Wen Yang Huo Xue"(温阳活血 warm the Yang and promote the blood circulation).The treating course was three months.The effects of these two kinds of therapy were different,group A was significantly better than group B(P<0.01).In group A,there was marked improvement in plasma creatinine concentration and creatinine clearance(P<0.01 and 0.001 respectively). Walser pointed out that the changes in renal function could be shown by the diagram of time and the reciprocal of creatinine concentration,which was almost on a straight line,and the slope indicated the speed of change in renal function.Six patients’data were plotted and compared with Waiter’s diagram.In the follow-up of 74 patients with plasma creatinine concentration over 5mg%,the one,two and three-year survival periods were 59.7%,29.0% and 8.0% respectively.It denotes that the prognosis of chronic renal failure is really very serious. This study emphasized the importance of"Tong Fu Xie Zhuo"in the treatment of uremia,the effect of the treatment could be better and stabler with addition of"Fu Zheng"(扶正,replenish the vitality).The discussion on the adverse effect of"Wen Yang"(温阳,warm the Yang)in the treatment of uremia indicated that this remedy should not be widely used.The application of"Tong Fu Xie Zhuo",instead of"Ping Gan Xi Feng"(平肝熄风,ease the liver and remove the wind-evil),is appropriate for the treatment of neurologic symptoms in uremia.

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