通脉灵对血小板超微结构影响的临床与实验研究

作者	单位
刘杰文	中国医学科学院血液学研究所
李景德	中国医学科学院血液学研究所
王书桂	中国医学科学院血液学研究所

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中文摘要:

在8例血栓闭塞性血管炎患者用通脉灵治疗前后的血小板超微结构观察中,发现患者治疗前的血小板体积较小、外形不规则、伪足长而多、α颗粒减少、致密颗枉少见;而治疗后血小板的体积趋于正常,外形较规则、伪足少、颗粒较多而明显,分布于细胞中央。在 BLM-A6诱致的小鼠肺毒性反应时,药物对血栓形成也有预防作用。因此认为通脉灵对抗血栓形成有一定意义。

英文摘要:

Effect of Tong Mal Lin on platelets from 8 patients with thromboangiitis obliterans and on platelets from the capillary of lung induced by the toxic response to Bleomycin A₆ in mice were studied by electron microscopy.The results showed that the platelets were small in size with long pseudopodia,number of granules in it was decreased,and few of dense body could be seen before treatment.After treatment of Tong Mai Lin,the size of platelet was normal,with regular shape,but the pseudopodia were reduced,number of granules became normal. The initial site of BLM-A₆ induced damage lay chiefly in the endothelial cell consisting of increased pinocytic vesicles and formation of pseudopodia-like protrusions.At early stage the endothelium was separated from the basal membranes with edematous fluid filled space.The platelets adhering to the endothelial surfaces were frequently seen,sometimes clumped together forming microthrombi.The fibrosis was localized.The myofibroblast proliferation and collagen hyperplasia in alveolar septa and occlusive capillary lumens might be seen at later stage,in the treated group the alveolar septa did not change. Microthrombi formation,myofibroblasts proliferation and hyperplasia of collagen could not be seen any more.It showed that effect of Tong Mai Lin on ultrastructure of the platelets was marked,its pharmacological actions might be an inhibition on contracture of endothelium and might indirectly prevent the microthrombi formation by improving endothelial function as well as by its anti-inflammatory activity.

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