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朱希伟,隋文作,印晓光,郝宏党.小蘖胺抗肿瘤作用的实验研究[J].中国中西医结合杂志,1986,(10):611-613,582
小蘖胺抗肿瘤作用的实验研究
Experimental Study on Anti-Tumor Action of Berbamine in Mice
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DOI:
中文关键词:  小蘖胺  抗肿瘤作用  小鼠移植性肿瘤  生命延长率  实验研究  肿瘤细胞  实验组  抑制作用  超微结构观察  汉防己甲素
英文关键词:
基金项目:
作者单位
朱希伟 辽宁中医学院 
隋文作 辽宁中医学院 
印晓光 辽宁中医学院 
郝宏党 辽宁中医学院 
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中文摘要:
      本文通过动物抗肿瘤实验,证明小蘖胺对小鼠 S180的抑制率为75~78%;对小鼠HAC 的生命延长率为68~80%;对小鼠 EAC 的生命延长率为68~80%。病理学及超微结构观察,提示实验组肿瘤细胞有坏死现象和代谢受阻情况。小蘖胺的急性 LD50为112±0.04mg/kg。
英文摘要:
      This paper reports on the effect of berbamine treatment of tumor in mice.After hypodermic transplantation of 4.0×105 S180cells and intraperitoneal transplantation of 4.0×105 HAC or EAC ascitic tumor cells,the mice in the berbamine treated group was given 20 mg/kg berbamine intraperitoneally,once daily for ten days.The growth suppressing rate of S180tumor cells was 75~78%,and the lifespan extension rate of the mice with HAC and EAC was 68~80% in the berbamine treated group.Light and electron microscopic examination showed that there were necrosis and metabolic disturbance in the tumor cells treated by berhamine.The experimental result showed that berbamine can suppress the transplanted tumor in mice effectively.
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