从尿中儿茶酚胺及cAMP、cGMP的排出量探讨中医寒证、热证的本质

Study on the Nature of"Cold"and"Heat"Syndromes in TCM by Determination on the Amount of Catecholamines and Cyclic Nucleotides Excreted in the Urine

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DOI：

中文关键词: 尿儿茶酚胺肾上腺髓质排出量正常对照组实热证功能活动系统功能肾阳虚高血压病寒证

英文关键词:

基金项目:

作者	单位
谢竹藩	北京医科大学
唐子进	北京医科大学
马珩	79级研究生桂林卫生局

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中文摘要:

本文通过尿中儿茶酚胺和环核替酸排出量的测定,探讨寒证、热证与植物神经、肾上腺髓质功能活动及第二信使系统之间的关系。虚寒患者尿中儿茶酚胺及 cAMP排出量降低,cGMP 增高,导致 cAMP/cGMP 比值下降,说明虚寒患者交感—肾上腺髓质系统功能低下而副交感系统兴奋性增高。热证患者,无论是实热还是虚热,其尿中儿茶酚胺及环核苷酸均增高,病变脏腑的不同和西医病种的不同并不影响这种变化趋势,说明交感—肾上腺髓质功能活动增强是热证的共性。

英文摘要:

Urine catecholamines(epinephrine,norepinephrine-and dopamine)and cyclic nucleotides(cAMP and cGMP)were assayed in 61 cases of various diseases and 25 healthy persons.According to traditional Chinese medicine these 61 cases were classified into 3 categories:heat syndrome of excess type(29 cases), heat syndrome of deficiency type(21 cases),and cold syndrome of deficiency type(11 cases).The catecholamines and cyclic nucleotidcs excreted in the urine were increased in heat syndrome either of excess type or of deficiency type.In the cold syndrome,on the contrary,urine catecholamines and cAMP were decreased,but cGMP was increased,causing marked lowering of cAMP/cGMP ratio.Variations of the diseases diagnosed according to Western medicine and the involved visceral organs(Zang-Fu,脏腑) determined in the traditional way made no difference to the tendency of the above-mentioned changes.Thus, these changes can be considered as the characteristic features of cold and heat syndromes,indicating hyperfunctioning of the sympathetico-adrenal medulla system in heat syndrome in contrast with hypofunctioning of sympathetic system and hyperfunctioning of the parasympathetic system in cold syndrome.

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