中药海黄散治疗上消化道出血50例疗效观察

This paper reports 50 patients with hemorrhage in upper GI tract treated by a Chinese herbal drug called Hat Huang San(海黄散,Powder of Sepium and Rhubarb)in our hospital during the period of 1984 to 1985.There were melena in all cases and hematemesis in 15 cases.The major causes of the bleeding were indiscretion on food taking and fatigue.There were 20 cases of duodenal ulcer,8 cases of gastric ulcer,10 chronic gastritis,6 antral gastritis,5 gastric cancer,1 carcinoma of pancreatic nead diagnosed by roentgenographic examination of GI series or gastroendoscopy.Among them,12 cases had massive bleeding, 22 medium and 16 mild.After treating the bleeding was stopped in 49 cases,only one case failed,the effective rate of hemostasis was 98%.The range of hemostatic time was between 12～72 hours,with 26.1 hrs. in average.In comparing with the control group(50 cases)treated with para-aminomethyl benzoic acid and cimetidine intravenously given,the range of hemostatic time was between 24 hrs.to 7 days,with an average of 50.6 hrs.,its effective rate was 96%.The difference between two groups was very significant(P<0.01). The mechanism of this beneficial effect of hemostasis obtained by applying Hat Huang San is probably the coordinating action of anthraquinone derivative,tannic acid and calcium ion which are released from the drug.It is emphasized that powder of Hat Huang San has optimal effect on mucosal lesion of inflammation, ulcer and hemorrhage in upper GI tract. The resource of Hat Huang San is abundant,its processing is simple,the price is cheap,in addition it has the advantage of rapid hemostatic effect,and is not limited by age and condition of disease.Therefore this method is worth further popularizing.

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