东北延胡索的药理实验研究

本文研究了东北延胡索的镇痛作用和某些心血管作用,并与延胡索进行了对比。小鼠腹腔或皮下注射30mg/kg、45mg/kg 东北延胡索总生物碱,用热板法和扭体法测定,均可显著延长疼痛反应时间及抑制扭体反应发生率。同剂量东北延胡索对扭体反应的抑制作用强于延胡索。东北延胡索延长小鼠缺氧状态下的存活时间,其作用亦强于延胡索。同剂量的东北延胡索与延胡索均能增加离体兔心冠脉流量、抑制心肌收缩力,并且对抗垂体后叶素引起的心电图 ST 段和 T 波的变化。

英文摘要:

Using benzene extracted of effect of analgesia and its action on cardiovascular system were studied.This alkaloid was compared with that of Corydalis yanhusuo extracted in the same way.The following results were obtained: 1.The effect of analgesia:（1）Heating plate method:Mice were injected intraperitoneally with this extract 30 mg/kg and 45 mg/kg.20 min.later,the responding time of algesthesia was markedly prolonged and sustained for 90 min.In comparison with the same dose of C.yanhusuo,it has the similar effect.（2） Method of cramping in mice:Mice were injected subcutaneously with the same dose of the extract.The frequency of cramping was 7.5±6.3 and 0 within 15 min.respectively.As compared with same dose of C. yanhusuo,the frequency of cramping was 15.5±9.5 and 12.2±7.0.Therefore this extract was more potent than that of C.yanhusuo. 2.Experiment on anoxia-tolerance in mice:The experimental group was administered intraperitoneally with the same dose of the extract,and showed markedly extended survival time for 72% and 142% respectively.The group of C.yanhusuo with the same dose was 8.8% and 28% only. 3.The effect on cardiovascular system:（1）Perfused experiment of isolated rabbit’s heart:Either this extract or C.yanhusuo administered same dose（0.3 mg and 1.0 mg）would inhibit the myocardial contraction significantly,and increase the coronary flow markedly.（2）Experiment of acute myocardial ischemia:The elevating ST-T wave of lead V₃ produced by pituitrin-induced ischemia in guinea pigs was opposed by intravenous injection 15 mg/kg of this extract.Similar effect was also observed with the same dose of C.yanhusuo.

关闭