大蒜素对实验性高胆固醇血症兔的抗血小板聚集作用

作者	单位
张胜乐	山东省医学科学院
徐英杰	山东省医学科学院
陆通	山东省医学科学院
李苙	山东省医学科学院
高春义	山东省医学科学院

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中文摘要:

用兔制成实验性高胆固醇血症动物模型,观察大蒜素对血小板聚集率、血小板内 cAMP 和 cGMP 等指标的动态变化。结果表明:大蒜素具有明显抑制高胆固醇血症引起的血小板聚集作用,这种作用是通过提高血小板内 cAMP 这一重要环节而实现的,与cGMP 无关。

英文摘要:

Thirty-two New Zealand rabbits weighing 1.5～2.5 kg were divided into three groups:group Ⅰ(the control group,n=10);group Ⅱ(n=11)and group Ⅲ(n=11).They were all fed a common-stock diet.Except for the control group,group Ⅱ received cholesterol(0.5 g/kg body weight)daily,while group Ⅲ was fed 0.5 g/kg of cholesterol plus the Allitridi(diallyl trisulfide,20 mg/kg).Blood cholesterol,platelet aggregation, platelet cAMP and cGMP index were determined by the usual techniques at fixed time.The observation was finished at the end of the 15th week.The rise in serum cholesterol was significantly reduced by Allitridi during the 15 weeks period of study.Platelet aggregation in group Ⅱ was significantly higher than that in group Ⅰ(P<0.05),while in group Ⅲ,it was close to the control group but significantly lower than that in group Ⅲ(P<0.01).There was a negative correlation between platelet cAMP and platelet aggregation(r= —0.42,P<0.05).Platelet cAMP in group Ⅲ was little higher than that in the control group(P>0.05),but significantly higher than that in group Ⅱ(P<0.001).There was no difference of platelet cGMP between group Ⅱ and group Ⅲ.It is suggested that Allitridi has a powerful anti-aggregating effect on platelet in hypercholesterolemic rabbits and its inhibition of platelet aggregation is mediated by an increase of platelet cAMP.

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