缺血性心脏病患者血浆TXB<sub>2</sub>、6-keto-PGF<sub>1α</sub>水平与中医证型关系的研究——缺血性心脏病本虚标实机理初探

A Study of the Relationship Between Plasma Thromboxane B2, 6-Keto-Prostaglandin F₁x Levels and TCM Differential Types of the Ischemic Heart Disease Patients

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中文关键词: 缺血性心脏病心脏病患者不稳定型心绞痛本虚标实证血浆陈旧性心肌梗塞急性心肌梗塞脑梗塞不同中医证型水平

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基金项目:

作者	单位
徐启营	黑龙江中医学院附属医院
贾宝善	黑龙江中医学院附属医院
东贵荣	黑龙江中医学院
石刚	黑龙江中医学院附属医院
徐凯	黑龙江中医学院附属医院

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中文摘要:

本文研究结果表明,血浆 TXB₂水平升高,6-keto-PGF_1α水平降低和 TXB₂/6-keto—PGF_1α比值升高,与缺血性心脏病的发生和中医本虚标实辨证有密切关系。可考虑作为缺血性心脏病本虚标实辨证的客观指标之一。TXA₂-PGI₂平衡失调是本虚标实辨证的病变基础之一。

英文摘要:

Through the analysis of TXB₂ and 6-keto-PGF_1αlevels in plasma of the patients with ischemic heart disease（IHD）and the study of relationship between them and the syndrome diffcrentiation of Ben（本,root cause）deficiency（BD）and Biao（标,symptomatic）excess（BE）in TCM,it confirmed that there was close relation between the increase of TXB₂ level,the elevation of TXB₂/6-keto-PGF_1αratio,the decrease of 6-keto-PGF_1αlevel and the onset of myocardial infarction,unstable angina and cerebral infarction.The patients with BD syndrome showed a marked decrease in 6-keto-PGF_1αlevel compared with the group of normal subjects and the patients with BE syndrome（P<0.01）.The patients with BE syndrome showed a marked increase in TXB₂ level in comparison with the normal control and the patients with BD syndrome （P<0.001）.The patients with both BD and BE syndrome showed a marked increase in TXB₂ level comparing with normal group and BD syndrome（P<0.001）.At the same time the patients with both BD and BE syndrome showed a marked decrease in 6-keto-PGF_1αlevel which is compared with normal persons and BE syndrome（P<0.01）.The group of BD syndrome.BE syndrome and both BD and BE syndrome showed a significant difference in TXB₂/6-keto-PGF_1αratio in comparing with the normal control;and the TXB₂/6-keto-PGF_1αratio showed a significant difference among the three groups.This result suggested that decrease in the level of 6-keto-PGF_1αin plasma might be a characteristic of the BD syndrome.The increase in level of TXB₂ in plasma might be a characteristic of the BE syndrome.However the increase in level of TXB₂ and the decrease in level of 6-keto-PGF_1αat the same time also showed that it might be a characteristic of both BD and BE syndrome.The levels of TXB₂,6-keto-PGF₁ and ratio of TXB₂/6-keto-PGF_1αin plasma might be one of the objective parameters for the syndrome differentiation of BD and BE in patients with IHD.The imbalance between TXB₂ and 6-keto-PGF_1αin plasma may be one of the basic pathological change in BD and BE syndrome in patients with IHD.To a certain extent,the change of balance regulating system of TXB,and 6-keto-PGF_1αlevels may reflect the interdependence and mutual condition of the physiological function and pathological change of vital energy and blood.Therefore the TXA₂ and PGI₂ in plasma may be the material base of the vital energy and blood.

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