降气定喘散对支气管哮喘患者心肺功能的作用

The folk herbal mixture Jiang Qi Ding Chuan San（JQDCS,降气定喘散）which has been widely used for the treatment of chronic asthma in Guangzhou.It consists of Ephedra sinice,Semen Sinapis albae,dried orange peel,Perilla frutescens,Semen Lepiapatalum and Cortex Mort albae.To evaluate whether JQDCS has a strong bronchodilative effect or not,the peak expiratory flow rate（PEFR）,heart rate（HR）and blood pressure（BP）were measured in eight male patients（20～60 years old）with chronic asthma.Comparative study of JQDCS given orally and single ephedrine administration was performed. During the consecutive 3-day investigation,routine oral aminophylline or β₂ receptor stimulant were ceased to use in all patients.By the use of single blind method patients received（at random）one of the following drugs at 8:00 A.M.（1）JQDCS granule,（2）ephedrine 36 mg in adjuvant particle,the amount of which was the same as that of JQDCS,（3）placebo.Drug was dissolved in boiling water,PEFR,HR and BP were measured prior and 15’,30’,60’,120’ and 180’ after medication.Another drug was them given on the second and third day.All parameters were re-measured as before. PEFR（246±66 L/min）showed no change except for that at 180’（increased by 10.8%,P<0.05）in the placebo group.A significant increase of mean PEFR at the above time interval by 7.1%,20.3%,29.0%, 40.3% and 37.6% respectively（comparing with premedicative determination 298±96 L/mix,P<0.01～0.05） were shown in ephedrine administration,and by 12.6%,23.9%,30.3%,41.1% and 61.0%,respectively（as compared with the value of premedication 236±68 L/min,all P<0.01）in JQDCS administration.The improvement rate of PEFR at 180’ in JQDCS group was significantly higher than that in ephedrine group （61.0% vs 37.4%,P<0.05）.There was no change of BP,HR after placebo administration.BP increased slightly but significantly（8～10 mmHg of systolic pressure）at 30’ and returned to normal at 180’ after giving ephedrine orally.Also,a significant increase of HR,6～10 beats/min,was shown from 60’～180’ after ephedrine administration.JQDCS had the same effect on BP and HR as that of ephedrine.We conclude that JQDCS has a better and longer bronchodilative effect as compared with ephedrine without increasing side effect.

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