| 孙福立,李德明.试用睡眠剥夺方法建立心虚证的动物模型[J].中国中西医结合杂志,1987,(1):35-37,6 |
| 试用睡眠剥夺方法建立心虚证的动物模型 |
| An Animal Model for Heart Deficiency Syndrome Induced by Sleep Deprivation |
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| DOI： |
| 中文关键词: 睡眠剥夺 动物模型 心虚证 方法建立 心率变异 大鼠 气阴两虚 功率谱 动物血 气虚证 |
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| 中文摘要: |
| 本文报道了用睡眠剥夺的小站台法,模拟中医理论的"惊"和"劳"等病因,在20只大鼠身上建立心虚证模型的实验。结果表明,它能够使实验动物产生某些心虚证的体征。并可通过控制睡眠剥夺的时间,选择性的造成类似心阴虚、心气虚或气阴两虚偏气虚证的动物模型。 |
| 英文摘要: |
| This paper reports that a model of heart deficiency syndrome was induced by a small platform method for sleep deprivation which can imitate"frightened"and"overfatigue"pathogenic factors of TCM theory. 20 rats of 200～250 g were divided into two groups:a sleep deprived group and a controlled one.Sleep deprivation was carried out on a small platform(d=4.5 cm,W/A>6.40)surrounded by water.The controlled animals were placed on a large platform(d=13.5 cm,W/A<1.73)in the same environment.Then the blood pressure and the ECG were measured and recorded respectively at the time of 24,48,72 and 96 hours.The heart rate variability(HRV)was analyzed with the spectral method.The results showed that the sleep deprivation could bring about some effects on heart deficiency in the experimental animals,e.g.the blood pressure was decreased,the mean heart rate increased and the HRV power spectrum in lower frequencies was also increased.Therefore,it indicated that the model for deficiency of heart Yin(阴),of heart Qi(气)and deficiency of both heart Qi and Yin could be induced selectively by controlling the duration of sleep deprivation. |
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