| 吕桂芝,黄衍川,高燕,彭玲,梁亚云,徐永福,王耐勤,李岩,汪堃仁.复方龙葵注射液对肝癌(H22)细胞的影响[J].中国中西医结合杂志,1987,(2):97-99,70 |
| 复方龙葵注射液对肝癌(H22)细胞的影响 |
| Effect of Long Kui Injection Co.on Hepatoma H22Ascites Tumour Cells in Mice |
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| DOI： |
| 中文关键词: 癌细胞 腹水型 注射液 酶活性 膜表面 肝癌 龙葵 磷酸二酯酶 复方中药 微绒毛 |
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| 摘要点击次数: 1952 |
| 全文下载次数: 1119 |
| 中文摘要: |
| 本实验应用复方龙葵注射液（龙葵、蛇莓、白英、当归、丹参、郁金的提取成份）连续作用于小白鼠肝癌(H22)腹水型癌细胞,观察到本药对肝癌腹水型癌细胞的增殖有明显的阻抑作用,抑制率可达87.35%;P 值<0.001,效果非常显著。同时观察到癌细胞膜表面上的磷酸二酯酶和（Na+-K+）-ATP 酶的活性明显下降,膜表面上的微绒毛明显消退。实验结果说明,本药具有高效的抗癌作用,其作用机理可能是通过抑制膜表面的磷酸二酯酶和（Na+-K+）-ATP 酶活性以提高细胞内 cAMP 水平,调控细胞的增殖和分化。 |
| 英文摘要: |
| This experiment was carried out in adult mice.Hepatoma H22ascites tumour’cells was injected intraperitoneally to produce a hepatoma H22ascites tumour model.On the 2nd day after inoculation,these animals were divided into two groups.Group 1 was injected intraperitoneaUy with 0.2 ml Long Kui injection co.every day for 8 days.which contained Solanum nigrum,Solamon lyratum.Duchesnea Indica.Angelica Sinensis,Curcuma aromatica and Salvia miltiorrhiza.Group 2 received same dose of saline as control. Results showed that this injection inhibited markedly the proliferation of hepatoma H22ascites tumour cells. The inhibitory rate was 87%,P<0.001.At the same time.the cAMP-phosphodiesterase and（Na+-K+）- ATPase activity on the cell membrane surface was decreased and the microvilli showed marked regression. These results indicated that the Long Kui injection co.was a potent anti-cancer drug,and it may increase intracellular cAMP level by inhibiting 3′,5′cAMP-PDE and（Na+-K+）-ATPase activity to modulate the proliferation and the differentiation of the cancer cells. |
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