| 戴尧仁,高崇明,田清涞,殷莹.施今墨抗衰老方制备液对小鼠脑和肝B型单胺氧化酶活性及果蝇寿命的影响[J].中国中西医结合杂志,1987,(4):224-225,197,198 |
| 施今墨抗衰老方制备液对小鼠脑和肝B型单胺氧化酶活性及果蝇寿命的影响 |
| Effect of Preparation of Shi Jinmo’s Anti-aging Recipe on B Type Monoamine oxidase Activity in Mice and Life Span of Drosophila melanogaster |
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| DOI： |
| 中文关键词: 施今墨 果蝇寿命试验 抗衰老作用 制备 鼠脑 果蝇平均寿命 抑制作用 单胺氧化酶活性 小鼠 和肝 |
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| 中文摘要: |
| 本文测定了用施今墨抗衰老方制备液饲喂90天后的小鼠脑和肝中 B 型单胺氧化酶(MAO-B)活性,发现该液可抑制小鼠脑中 MAO-B 活性达50%,而肝中 MAO-B 活性只有较轻微的抑制。果蝇寿命试验表明,该液可延长果蝇平均寿命约21%。表明施今墨抗衰老方确实具有一定的抗衰老作用。 |
| 英文摘要: |
| The preparation of the anti-aging recipe of Shi Jinmo,a famous experienced doctor of TCM,showed about 50% inhibition on brain MAO-B activity when the preparation was fed to 6-month male NIH mice for 90 days.The inhibitory effect of MAO-B activity partly explained the anti-aging efficacy of Shi Jinmo’s remedy in terms of the regulation on brain level of monoamine transmitters,the shift of which was considered as mainspring of the central aging clock located in hypothalamus.In an in vitro experiment about 57% inhibition of mouse brain MAO-B activity was shown by the preparation of Shi Jinmo’s recipe.The result was consistent with that of in vivo experiment,suggesting a direct inhibitory effect of the medicines on brain MAO-B activity.A weak inhibition(about 20%)on liver MAO-B activity by the preparation was also observed.This met the requirement of a monoamine oxidase inhibitor to be used clinically,since an appropriate level of MAO activity in liver was required for the degradation of certain kinds of monoamines in order to avoid their harmful effect.Feeding the preparation showed no influence on the average body weight of animals,indicating that the medicines had no adverse effects on animal growth.In the life span test using female fruit flies,the preparation was fed to the flies for 3 days.The number of survivors was counted up every day and the life span of each fruit fly was recorded.The results showed that the average life span of Drosophila melanogaster was conspicuously increased by this medical treatment(21.63%). The results were evidences on the anti-aging effect of Shi Jinmo’s recipe in terms of the biology of aging. |
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