| 钱止维,毛淑娟,蔡晓晨,张秀龙,高凤仙,吕妙飞,邵幸曙,李玉英,周园,史连永,侯云德.黄芪与干扰素治疗宫颈糜烂及抗病毒的协同作用[J].中国中西医结合杂志,1987,(5):268-269,287,259 |
| 黄芪与干扰素治疗宫颈糜烂及抗病毒的协同作用 |
| Synergism of Astragalus membranaceus with Interferon in theTreatment of Cervical Erosion and Their Antiviral Activities |
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| DOI： |
| 中文关键词: 宫颈糜烂 基因工程干扰素 干扰素治疗 抗病毒作用 协同作用 病毒分离 临床疗效 治疗后 阳性率 分离率 |
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| 摘要点击次数: 1698 |
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| 中文摘要: |
| 本文采用黄芪加基因工程干扰素和单独采用基因工程干扰素治疗宫颈糜烂164例,对其临床疗效和单纯疱疹病毒的分离率进行了比较。结果表明:黄芪与干扰素联合应用的显效率(60.7%)明显高于单独应用干扰素组(31.8%)(P<0.02),而与加倍量的干扰素组相当(59.3%)(P>0.05)。黄芪加干扰素组在治疗后病毒分离的阳性率由30.4%下降到3.8%;而单纯干扰素组则由33.3%下降到10%。 |
| 英文摘要: |
| In this paper a double blind controlled study on the efficacy of Astragalus membranaceus(AM) combined with recombinant human _αD interferon(rIFN)was carried out in the treatment of 164 patients with cervical erosion(50 cases of mild type,89 moderate and 25 severe).Patients’ age ranged from 24 to 56 (in average 35 years).Patients selected were divided into 3 groups at random:rIFN group Ⅰ(2.5μg rIFN× 6),rIFN group Ⅱ(1.25μg rIFN×6)and AM+rIFN group(1.25μg of rlFN×6 and 0.05g of AM×6). Drugs were administered by pasting using two pieces of gauze with 3 cm in diameter soaked with 0.5 ml of a solution containing the above-mentioned rIFN or AM and rIFN,twice weekly for three weeks.Before treatment and 3 days after termination of one course treatment the erosive area on the cervix was measured for each ease and the cervical swabs were simultaneously taken for herpes simplex virus isolation using suckling rabbit kidney cell culture.Results obtained from clinical observation indicated that the markedly improved rate in AM and rIFN combination group(60.7%)was significantly higher than that in rIFN group Ⅱ(31.8%)(P<0.02)and was similar to that in rIFN group Ⅰ(59.3%)(P>0.05),in which the rIFN dosage was doubled.The clinical efficacy of the patients was followed up six months after termination of the treatment.The markedly improved rate in AM and rIFN combination group(73.2%)appeared still significantly higher than that in rIFN group Ⅱ(38.9%)(P<0.05).Results obtained from the virological study showed that the herpes simplex virus isolation rate in AM and rIFN combination group markedly dropped from 30.4% before treatment to 3.8%,after treatment as compared with the reduction from 33.3% to 10% in rIFN group Ⅰ and Ⅱ.Results obtained suggested that AM may be used as a synergist in the rIFN treatment of chronic cervieitis. |
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