| 邱佳信,杨金坤.健脾理气、清热解毒、软坚化痰方剂治疗晚期肝癌的临床观察及实验研究[J].中国中西医结合杂志,1987,(5):275-277,260 |
| 健脾理气、清热解毒、软坚化痰方剂治疗晚期肝癌的临床观察及实验研究 |
| Use of "SRRS" Recipe on Treatment of Late Stage Liver Cancer Patients and Their Experimental Investigations |
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| DOI： |
| 中文关键词: 晚期肝癌 清热解毒 实验研究 软坚化痰 健脾理气 启动作用 原发性肝癌 方剂 肝癌患者 治疗方法 |
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| 中文摘要: |
| 依据中医辨证论治的原则,应用健脾理气、清热解毒、软坚化痰方剂治疗晚期肝癌一年生存率为32.5%。实验研究提示本方剂中的某些成份可能对人体肝癌细胞有一定的杀伤作用;有反突变和反启动作用;有抑制 Lewis 瘤肺转移作用。 |
| 英文摘要: |
| Clinical and experimental investigations of"strengthening the spleen,regulating the flow of vital energy, removing the toxic heat,softening the hard lumps and resolving the phlegm（SRRS）"recipe in treating late stage liver cancer were made in our hospital.According to the theory of"different diseases be treated with same method"of the traditional Chinese medicine,this recipe in treating some cases of liver cancer was used.Results:（1）The survival rate（1 year）of the primary carcinoma of the liver:SRRS group was 31% （control 4.5%,P<0.05）.（2）The survival rate（1 year）of secondary carcinoma of the liver:SRRS group was 33.8%（control 16%,P<0.05）. In the experimental investigation,the mutation assay(V79cell)for initiation model and metabolic cooperation for promotion model were chosen to answer whether the multi-stage concept of carcinogenesis （initiation and promotion）could be influenced by traditional Chinese drugs of this recipe used.Experimental results showed that some traditional Chinese drugs do have anti-mutation and other drugs have anti-promotion effects.It suggests that the incidence of malignant tumors could be reduced and the liver cancer be treated by using these Chinese drugs,In addition to the anti-mutation and anti-promotion effects, the experimental results also showed that some Chinese drugs of SRRS recipe had the cytotoxicity in human liver cancer cell（7402）,which also arrested metastatic effect of the Lewis lung carcinoma in the C57BL mouse strain. SRRS recipe:Jianpi Liqi（健脾理气）,Qingre Jiedu（清热解毒）,Ruanjian Huatan（软坚化痰）. |
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